All aspects of nitrate therapy, including conventional and new formulations and delivery systems, are covered in this book. For each drug the formulation, mechanism of action, indications, effects, adverse reactions and special problems are systematically described. The use of nitrates in specific population groups, such as infants, children and the elderly, is dealt with separately. The book is updated, based not only on the world literature but also on the most recent conference presentations, and provides the reader with thorough and practice-oriented coverage.

A. Introduction and Mechanism.- 1. Introduction.- 2. The Mechanism of Action of Nitrates at the Cellular Level.- B. Indications.- 3. Stable Angina Pectoris.- 4. The Mechanism of Action of Nitrates in Angina Pectoris.- 5. Nitrates Compared and Combined with Other Antianginal Drugs.- 6. Unstable Angina Pectoris.- 7. Long-Term Use of Nitrates in Angina Pectoris.- 8. Silent Ischemia.- 9. Acute Myocardial Infarction.- 10. Congestive Heart Failure.- 11. Congestive Heart Failure and Valvular Diseases.- 12. Long-Term Nitrate Therapy in Congestive Heart Failure.- 13. Nitrates Combined and Compared with Other Drugs in Congestive Heart Failure.- 14. Systemic Hypertension, Arrhythmias and Cardiac Surgery.- 15. Pulmonary, Abdominal, and Peripheral Vascular Effects.- 16. Non-Cardiovascular Indications for Nitrates.- 17. Nitrates in Children and the Elderly.- C. Nitrate Formulations and Routes of Administration.- 18. Sublingual Tablets and Oral Spray.- 19. Intravenous Administration of Nitrates.- 20. Intracoronary Administration of Nitrates.- 21. Oral Administration of Nitrates.- 22. Mononitrates.- 23. Transdermal Administration of Nitrates.- 24. Buccal Nitroglycerin.- D. Pharmacology.- 25. Clinical Pharmacology.- 26. Side Effects and Drug Interactions.- 27. Dosage and Administration.- E. Conclusions.- References.