Isoenzymes in Biology and Medicine attempts to give an account of the study of isoenzymes in relation to humans, animals, insects, higher plants, fungi, protozoa, algae, and bacteria. This book discusses the chemical structure, physiological aspects, metabolic role, and function of isoenzyme observations in genetic, ontogenic, and phylogenic studies. A detailed account of the use of isoenzyme in the diagnosis and pathogenesis of disease and control of therapy is also provided. This text likewise considers the isoenzymes of the oxidoreductases, transferases, and hydrolases, including its relation to clinical medicine. This publication is intended for biochemists, biologists, clinical biochemists and physicians.

Preface
Acknowledgments

I. Introduction

II. Isoenzymes of the Oxidoreductases

1. Lactate Dehydrogenase

2. Malate Dehydrogenase

3. Isocitrate Dehydrogenase

4. Galactose Dehydrogenase

5. Glutamate Dehydrogenase

6. Glucose-6-Phosphate Dehydrogenase

7. Phosphogluconate Dehydrogenase

8. Alcohol Dehydrogenase

9. Catalase

10. Multiple Dehydrogenase Activities

III. Isoenzymes of the Transferases

1. Aspartate Aminotransferase

2. Hexokinase

3. Creatine Kinase

4. Pyruvate Kinase

5. Carbonic Anhydrase

IV. Isoenzymes of the Hydrolases

1. Non-Specific Alkaline Phosphatase

2. Specific Alkaline Phosphatases

3. Acid phosphatase

4. Esterases

5. Arylamidase

6. Amylase

7. Glutaminase

8. Miscellaneous Enzymes

9. Aldolase

V. Phsiological Aspects and Metabolic Role

1. Lactate Dehydrogenase

2. Malate Dehydrogenase

3. Aspartate Kinase

4. Aminotransferases

5. Creatine Kinase

6. Hexokinase

7. Hydrolases

8. Other Enzyme Systems

VI. Genetic Studies

1. Lactate Dehydrogenase

2. Isocitrate Dehydrogenase

3. Phosphogluconate Dehydrogenase

4. Glucose-6-Phosphate Dehydrogenase

5. Adenylate Kinase

6. Phosphoglucomutase

7. Esterases

8. Alkaline Phosphatase

9. Acid Phosphatase

10. Amylase

11. Leucine Aminopeptidase

VII. Ontogenic and Phylogenic Studies

1. Ontogeny

2. Evolutionary and Phylogenic Studies

VIII. Insects, Plants and Lower Organisms

1. Insects

2. Higher Plants

3. Fungi

4. Protozoa

5. Algae

6. Bacteria

IX. Isoenzymes in Relation to Clinical Medicine

1. Lactate Dehydrogenase

2. Aspartate Aminotransferase

3. Creatine Phosphotransferase

4. Alkaline Phosphatase

5. Acid Phosphatase

6. Arylamidase

7. Esterases

8. Isoenzymes, in Cancer

X. Technical Methods

1. Separation Techniques

2. Methods of Demonstrating Enzyme Activity

3. Immunological Techniques

References

Appendix

Author Index

Subject Index