During the 10 years since the last edition of this volume our knowledge on malignant lymphomas, especially on extranodal lymphomas, has increased. This volume is an expanded and completely revised edition, now based on the WHO classification. The parallels to the updated Kiel classification and the REAL classification are indicated. The information is organized in organ-specific chapters, comprising the well-known nodal lymphoma entities as well as all known extranodal lymphomas and the different organ-specific clinico-pathological entities: lymphomas of the spleen, the gastrointestinal tract, the skin, etc. In addition to the morphology, the major immunohistochemical, molecular genetic, and clinical data are included in each chapter.

1 History of Lymphoma Classification.- 1.1 Introduction.- 1.2 The Kiel Classification.- 1.3 The REAL Classification Proposal.- 1.4 The WHO Classification.- References.- 2 Current Status of Lymphoma Classification.- 2.1 Introduction.- 2.2 Small- and Large-Cell Versus Low- and High-Grade.- 2.3 Primary Versus Secondary Lymphoma.- 2.4 Definition of Immunocytoma and Its Border with Marginal Zone B-Cell Lymphoma.- 2.5 Indistinct Border Between Nodal Marginal Zone B-Cell Lymphoma and Follicular Lymphoma with Marginal Zone Differentiation.- 2.6 Grading of Follicular Lymphoma.- 2.7 Distinction Between Diffuse Large B-Cell Lymphoma and Burkit's Lymphoma: Reproducibility and Value of Subclassification.- 2.8 Problems in Reproducibly Recognizing Anaplastic Large-Cell Lymphoma and Lymphoblastic Lymphoma on Purely Morphological Grounds.- 2.9 Is Peripheral T-Cell Lymphoma, Unspecified a Distinct Clinicopathological Entity or a Catchall Term?.- 2.10 Neither the WHO nor the EORTC Classification of Cutaneous Lymphoma Covers Today's Knowledge.- References.- 3 Epidemiology.- 3.1 Introduction.- 3.2 Statistical Data of the Kiel Lymphoma Registry.- 3.2.1 Age and Sex Distribution.- Malignant Lymphoma of Childhood.- References.- 4 Nodal B-Cell Lymphoma.- 4.1 Precursor B-Cell Lymphoblastic Leukemia.- 4.2 Peripheral B-Cell Lymphoma.- 4.2.1 Small-B-Cell Lymphoma.- 4.2.1.1 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma.- 4.2.1.2 Lymphoplasmacytic Lymphoma - Partially Corresponding to Macroglobulinemia Waldenström.- 4.2.1.3 Hairy Cell Leukemia.- 4.2.1.4 Plasmacytoma.- 4.2.1.5 Nodal Marginal Zone B-Cell Lymphoma.- 4.2.1.6 Follicular Lymphoma.- 4.2.1.7 Mantle Cell Lymphoma.- 4.2.2 Large-B-Cell Lymphoma.- 4.2.2.1 Diffuse Large-B-Cell Lymphoma - Common Features.- 4.2.2.2 Diffuse Large-B-Cell Lymphoma - Morphological Variants.- 4.2.2.3 Diffuse Large-B-Cell Lymphoma - Clinical Variants.- 4.2.3 Burkitt's Lymphoma.- References.- 5 Nodal and Leukemic NK/T-Cell Lymphoma.- 5.1 Precursor T-Lymphoblastic Leukemia/Lymphoma.- 5.2 Peripheral NK/T-Cell Lymphoma.- 5.2.1 Peripheral NK/T-Cell Lymphoma - Predominately Leukemic.- 5.2.1.1 T-Cell Chronic Lymphocytic/Prolymphocytic Leukemia.- 5.2.1.2 Adult T-Cell Leukemia/Lymphoma.- 5.2.2 Peripheral NK/T-Cell Lymphoma Predominately Nodal.- 5.2.2.1 Angioimmunoblastic T-Cell Lymphoma.- 5.2.2.2 Peripheral T-Cell Lymphoma, Unspecified.- 5.2.2.3 Mycosis Fungoides/Sézary's Syndrome Secondary to the Lymph Node.- 5.2.2.4 Anaplastic Large-Cell Lymphoma (T and Null Types).- References.- 6 Extranodal Lymphoma.- 6.1 Introduction.- 6.2 Gastrointestinal Lymphoma.- 6.2.1 B-Cell Lymphoma.- 6.2.1.1 Extranodal Marginal Zone B-Cell Lymphoma of MALT.- 6.2.1.2 Intestinal Follicular Lymphoma.- 6.2.1.3 Multiple Lymphomatous Polyposis - Intestinal Mantle Cell Lymphoma.- 6.2.1.4 Diffuse-Large-B-Cell Lymphoma of Gastrointestinal Tract.- 6.2.1.5 Burkitt's Lymphoma of the Gastrointestinal Tract.- 6.2.2 Primary Gastrointestinal T-Cell Lymphoma.- 6.2.2.1 Enteropathy-Type T-Cell Lymphoma.- 6.2.2.2 NK/T-Cell Lymphoma, Nasal Type.- 6.2.2.3 Anaplastic Large-Cell Lymphoma.- 6.3 Lymphoma of the Upper Aerodigestive Tract.- 6.3.1 Lymphoma of the Oral Cavity.- 6.3.2 Lymphoma of Waldeyer's Ring and the Pharynx.- 6.3.3 Lymphoma of the Nasal Cavity and Paranasal Sinuses.- 6.3.3.1 B-Cell Lymphoma.- 6.3.3.2 Extranodal NK/T-Cell Lymphoma - Nasal Type.- 6.3.4 Lymphoma of the Larynx and Trachea.- 6.4 Malignant Lymphoma of the Major Salivary Glands.- 6.5 Lymphoma of the Eye, Lachrymal Glands, and Orbit.- 6.5.1 Lymphoma of the Conjunctiva, Eyelids, Lachrymal Glands, and Orbit.- 6.5.2 Lymphoma of the Uvea and Retina (Similar to CNS Lymphoma).- 6.5.3 Primary Lymphoma of the Eye, Lachrymal Glands, and Orbit.- 6.6 Lymphoma of the Mediastinum.- 6.6.1 Mediastinal (Thymic) Large-B-Cell Lymphoma.- 6.6.2 Extranodal Marginal Zone B-Cell Lymphoma of the Thymus.- 6.6.3 Mediastinal Involvement in Precursor T- or B-Cell Lymphoblastic Lymphoma.- 6.6.4 Mediastinal Involvement in Small-B-Cell Lymphoma.- 6.6.5 Mediastinal Involvement in Large-B-Cell Lymphoma Other Than Primary Mediastinal Large-B-Cell Lymphoma and Burkitt's Lymphoma.- 6.6.6 Mediastinal Involvement in NK/T-Cell Lymphoma.- 6.7 Lymphoma of the Lung.- 6.7.1 Primary Lymphoma of the Lung.- 6.7.1.1 Extranodal Marginal Zone B-Cell Lymphoma of MALT.- 6.7.1.2 Primary Diffuse Large-B-Cell Lymphoma of the Lung.- 6.7.1.3 Primary Lung Intravascular Large-B-Cell Lymphoma.- 6.7.1.4 Large B-Cell Lymphoma Secondary to Liebow's Lymphomatoid Granulomatosis.- 6.7.1.5 Primary Lung Plasmacytoma.- 6.7.1.6 Primary NK/T-Cell Lymphoma of the Lung.- 6.8 Lymphoma of the Pleura.- 6.8.1 Primary Lymphoma of the Pleura.- 6.8.1.1 Primary Effusion Lymphoma.- 6.8.1.2 Pyothorax-Associated Primary Lymphoma.- 6.8.2 Secondary Pleural Lymphoma.- 6.9 Lymphoma of the Heart.- 6.9.1 Primary Cardiac Lymphoma.- 6.10 Splenic Lymphoma.- 6.10.1 Primary Splenic Lymphoma or Lymphoma with a Splenic Predominance.- 6.10.1.1 Hairy Cell Leukemia.- 6.10.1.2 Splenic Marginal Zone Lymphoma.- 6.10.1.3 Primary Splenic Lymphoplasmacytic Lymphoma.- 6.10.1.4 Plasmacytoma.- 6.10.1.5 B-Prolymphocytic Leukemia.- 6.10.1.6 Large B-Cell Lymphoma of the Spleen.- 6.10.1.7 Hepatosplenic T-Cell Lymphoma.- 6.10.1.8 T-Cell Large Granular Lymphocytic Leukemia.- 6.10.1.9 Other Types of Lymphoma.- 6.10.2 Secondary Splenic Lymphoma.- 6.10.2.1 Small-B-Cell Lymphoma.- 6.10.2.2 Other Types of B-Cell Lymphoma.- 6.10.2.3 Peripheral NK/T-Cell Lymphoma.- 6.10.2.4 Precursor Cell Neoplasias: B- and T-Lymphoblastic Lymphoma.- 6.11 Lymphoma of the Liver.- 6.11.1 Primary Lymphoma of the Liver.- 6.11.1.1 Primary Lymphoma Presenting as a Tumorous Infiltrate of the Liver.- 6.11.1.2 Primary Hepatic Lymphoma Presenting as Severe Hepatic Disease.- 6.11.2 Secondary Lymphoma of the Liver.- 6.12 Lymphoma of the Breast, Reproductive, and Urinary Systems.- 6.12.1 Malignant Lymphoma of the Breast.- 6.12.1.1 Primary Lymphoma of the Breast.- 6.12.1.2 Secondary Lymphoma of the Breast.- 6.12.2 Malignant Lymphoma of the Uterus.- 6.12.2.1 Primary Uterine Lymphoma.- 6.12.2.2 Addendum: Primary Lymphoma of the Vagina.- 6.12.2.3 Secondary Uterine and Vaginal Lymphoma.- 6.12.3 Malignant Lymphoma of the Ovary.- 6.12.3.1 Primary Lymphoma of the Ovary.- 6.12.3.2 Secondary Lymphoma of the Ovary.- 6.12.4 Lymphoma of Testis.- 6.12.5 Malignant Lymphoma of the Prostate.- 6.12.6 Lymphoma of the Kidney.- 6.12.6.1 Primary Lymphoma of the Kidney.- 6.12.6.2 Secondary Kidney Lymphoma.- 6.12.7 Malignant Lymphoma of the Urinary Bladder.- 6.13 Endocrine Gland Lymphoma.- 6.13.1 Malignant Lymphoma of the Thyroid Gland.- 6.13.2 Malignant Lymphoma of the Adrenal Gland.- 6.14 Cutaneous Lymphoma.- 6.14.1 Primary Cutaneous B-Cell Lymphoma.- 6.14.1.1 Cutaneous Marginal Zone B-Cell Lymphoma/SALT.- 6.14.1.2 Follicular Lymphoma.- 6.14.1.3 Plasmacytoma.- 6.14.1.4 Diffuse Large-B-Cell Lymphoma.- 6.14.2 Cutaneous T-Cell Lymphoma.- 6.14.2.1 Mycosis Fungoides - Classical Type.- 6.14.2.2 Sézary's Syndrome.- 6.14.2.3 Primary Cutaneous CD30+ T-Cell Lymphoproliferative Disorders.- 6.14.2.4 Primary Cutaneous NK/T-Cell Lymphoma.- 6.15 Lymphoma of Soft Tissues.- 6.16 Lymphoma of the Bone.- 6.16.1 Primary Lymphoma of Bone…