Organische Aminoverbindungen spielen in der pharmazeutischen Industrie und im Pflanzenschutz eine wichtige Rolle. Viele bioaktive Substanzen verdanken entweder ihre Struktur oder ihre Wirksamkeit den Aminogruppen im Molekül. Moderne Methoden zur Einführung von Aminogruppen sind deshalb von großer Bedeutung für Synthesechemiker und Produktentwickler.
Dieses Buch bietet nun erstmals einen Überblick über die neueren und effektiveren Aminierungsmethoden. Was bisher nur mühsam durch Recherche in vielen verschiedenen Journalen zugänglich war, ist hier von namhaften Experten für den Chemiker in der Praxis beschrieben. Insbesondere die neueren katalytischen Aminierungen haben die Chemie der organischen Aminoverbindungen revolutioniert - hier sind sie beschrieben.
Autorentext
Alfredo Ricci is full professor in Organic Chemistry at the Chemistry Department of the Faculty of Industrial Chemistry. He was appointed in Florence where he spent part of his career covering for many years the roles of Department head and Director of the National Research Council. 1990 he moved to the University of Bologna. Professor Ricci has authored more than 250 scientific publications and received several scientific awards, including the 2000 French-Italian Prize for Synthetic Organic Chemistry and in 2005 the "A. Mangini" Gold Medal. Since 1995 he is member of the 'Honorary Advisory Board' of Synlett and in 2000 served as editor of the Wiley-VCH book "Modern Amination Methods".
Zusammenfassung
Organic compounds containing amino groups are at the center of modern organic chemistry, and are widely used in the pharmaceutical industry, crop protection, natural product chemistry, and in advanced materials. Modern methods for the introduction of the amino group are therefore of major importance to synthetic chemists and product developers.
Over the last decade, many methods have been developed to generate new C-N bonds. At the same time, the pharmaceutical and chemical industry was rapidly moving away from the development of racemic compounds to the direct synthesis of enantiomerically pure materials. The articles of this book, written by internationally recognized experts, thus focus on asymmetric synthesis.
The most recent catalytic amination methods have particularly revolutionized the chemistry of amino compounds - and you find them all in this first comprehensive overview.
Inhalt
Design and preparation of (salen)Mn complexes and their use as aminating agents in the synthesis of aminoketones and of aminosaccarides by reaction with olefins
Stereoselctive electrophilic amination with sulfonyl carbamates and azodicarboxylates
Transition Metal-Catalysed Amination to form Aromatic Carbon-Nitrogen Bonds
Glycosylamines as the Stereodifferentiating Tools in Enantioselective Synthesis of Amino Acids and N-Heterocycles
Allylic Amination Reactions
Chiral nitrido-MN complexes and their use in asymmetric synthesis of aziridines
Asymmetric electrophilic amination