A comprehensive review of the impact of dietary nutraceuticals on platelet function and its relationship to cardiovascular disease
Nutraceuticals and Human Blood Platelet Function offers a summary of the most current evidence on the effects of anti-platelet factors isolated mainly from food and natural sources, their structure function relationship, bioavailability, mechanisms of actions, and also information on human trials data. The author--a noted expert in the field-- explores platelet function and their roles in development of CVD, functional foods and bioactive compounds in CVD risk factors. The author highlights platelets, their mechanisms of actions, data from epidemiological studies, structure-function relationship clinical trial data, ex vivo and in vitro data.
This important resource will focus primarily on human studies and emphasize functional and physiological implications of the nutritional impact on platelet function and CVD that could be an important approach to highlight the concept of preventive CVD nutrition. An authoritative text, Nutraceuticals and Human Blood Platelet Function:
* Offers a unique resource that connects nutrition with platelet function and its impact on cardiovascular disease
* Contains an evidenced-based approach, including data from human and animal clinical studies
* Reveals the impact of bioactive compounds and their effect on platelets
* Presents a text that is authored by an expert with vast experience in the field of nutrition and platelet function
Written for professionals, academics, researchers, and students associated in the area of nutrition, Nutraceuticals and Human Blood Platelet Function offers a review of the most current research on the effects of platelet function and their roles in development of CVD, functional foods and bioactive compounds in CVD risk factors.
Autorentext
DR. ASIM K. DUTTAROY is Professor of Clinical Nutrition at the University of Oslo, Norway. He has been working in the human platelet field since 1985, and has conducted groundbreaking research on anti-platelet factors in fruits and vegetables. Dr. Duttaroy's writing has been featured in numerous scientific journals across the globe.
Klappentext
A Comprehensive Review of the Impact of Dietary Nutraceuticals on Platelet Function and Its Relationship to Cardiovascular Disease
Nutraceuticals and Human Blood Platelet Function collates the latest research on platelet behavior and naturally sourced anti-platelet factors, and explores these topics within the context of cardiovascular health. Written by a leading expert in food science and nutrition, it authoritatively examines the functional and physiological roles of nutrition in the prevention of cardiovascular disease (CVD), and grounds its findings in data from epidemiological studies and ex vivo and in vivo clinical trials.
The author provides detailed explanations of the role of platelet function in CVD development, with anti-platelet factors, functional foods, and their bioactive compounds assessed as they relate to CVD risk factor reduction. Covering structure-function relationships, bioavailability, mechanisms of action, and more, this in-depth exploration:
- Connects nutrition with platelet function and its impact on cardiovascular disease
- Identifies functional foods and outlines the impact of their bioactive compounds upon platelets
- Takes an evidence-based approach, with data drawn from human and animal studies
- Is authored by an expert with many years' experience in the field of food science
Suitable for professionals, academics, researchers, and students alike, Nutraceuticals and Human Blood Platelet Function offers essential and up-to-date insights into platelet function, cardiovascular health, and the preventative capabilities of dietary and nutritional factors.
Inhalt
1 Human Blood Platelets and Their Role in the Development of Cardiovascular Disease 1
Abbreviations Used in This Chapter 1
1.1 Introduction 1
1.2 Human Blood Platelets: Structure and Function 4
1.3 Platelet Activation Pathways 10
1.4 Platelets and Vessel Wall Interactions 12
1.5 Roles of Platelets in Atherosclerosis and Inflammatory Processes 13
1.6 Platelets and Their Role in the Development of Cardiovascular Disease 17
1.7 Conclusions 22
References 22
2 Epidemiology of Cardiovascular Disease 29
Abbreviations Used in This Chapter 29
2.1 Introduction 29
2.2 Dietary Lipids and Cardiovascular Disease 32
2.3 Environmental Factors and Cardiovascular Disease 34
2.4 Genetic Basis of Cardiovascular Disease Incidence 35
2.5 Fruits and Vegetables Consumption and Cardiovascular Disease Risk Reduction 37
2.6 Conclusions 40
References 40
3 n3 Fatty Acids and Human Platelets 47
Abbreviations Used in This Chapter 47
3.1 Introduction 47
3.2 Epidemiology of n3 Fatty Acids Intake and Cardiovascular Disease 51
3.3 n3 Fatty Acids and Platelet Function 52
3.4 Platelet Function and Eicosanoids 56
3.5 Clinical Trials with n3 Fatty Acids 59
3.6 Dietary Recommendation and Sources of n3 Fatty Acids 61
3.7 Conclusions 62
References 62
4 Effects of Garlic, Onion, Ginger, and Turmeric on Platelet Function 69
Abbreviations 69
4.1 Introduction 69
4.2 Effects of Garlic (Allium Sativum) on Platelet Function 71
4.3 Effects of Onion (Allium Cepa L.) on Platelet Function 74
4.4 Effects of Ginger (Zingiber Officinale) on Platelet Function 75
4.5 Effects of Turmeric (Curcuma Longa) on Platelets 76
4.6 Conclusions 78
References 79
5 Herbs and Platelet Function 83
Abbreviations Used in This Chapter 83
5.1 Introduction 83
5.2 In Vitro Platelet Aggregation Studies: Effects of Different Herb Extracts 87
5.2.1 Andrographis (Andrographis Paniculata) 89
5.2.2 Cranberry (Vaccinium Macrocarpon) 90
5.2.3 Feverfew (Tanacetum Parthenium) 90
5.2.4 Green Tea (Camellia Sinensis) 91
5.2.5 Hawthorn (Crataegus Oxyacantha) 92
5.2.6 Horse Chestnut (Aesculus Hippocastanum) 92
5.2.7 Motherwort (Leonurus Japonicus) 93
5.2.8 St John's Wort (Hypericum Perforatum) 93
5.2.9 Willow Bark (Salix Alba) 94
5.3 Effects of Herbs on Signaling Molecules in Human Platelets 95
5.4 Conclusions 97
References 98
6 Tomato Extract and Human Platelet Functions 101
Abbreviations Used in This Chapter 101
6.1 Introduction 101
6.2 Epidemiology of Tomato Consumption and Cardiovascular Disease Risk Reduction 104
6.3 In Vitro Studies with WaterSoluble Tomato Extract on Human Blood Platelet Aggregation 105
6.4 Fruitflow®: Compositional and Structural Aspects 111
6.5 Human Trials 112
6.6 Comparing the Dietary AntiPlatelet Fruitflow® with the AntiPlatelet Drug Aspirin 115
6.8 EFSA Approval of Fruitflow® 117
6.8 Conclusions 117
References 118
7 Dietary Nitrates and Their AntiPlatelet Effects 125
Abbreviations Used in This Chapter 125
7.1 Introduction 125
7.2 Nitrate and Cardiovascular Health 129
7.3 Effects of Nitrates on Human Blood Platelet Function In Vitro 131
7.4 Clinical Studies with Dietary Nitrate: Effects on Ex Vivo Platelet Function 133
7.5 Conclusions 134
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