Here, front-line researchers in the booming field of nanobiotechnology describe the most promising approaches for bioinspired drug delivery, encompassing small molecule delivery, delivery of therapeutic proteins and gene delivery. The carriers surveyed include polymeric, proteinaceous and lipid systems on the nanoscale, with a focus on their adaptability for different cargoes and target tissues.
Thanks to the broad coverage of carriers as well as cargoes discussed, every researcher in the field will find valuable information here.
Autorentext
Professor Zhongwei Gu received his B. Sci. and M. Sci in Polymer Science from Peking University, prior to serving as a senior visiting scholar in the Research Triangle Institute, RTP and the University of Utah, respectively from 1984 to 1986 and 1991 to 1993. He was appointed as a professor in 1994, and presently serves as the chief scientist of the National Basic Research Program of China (the 973 program), director of the National Engineering Research Center for Biomaterials at Sichuan University, vice-chairman of the Chinese Society for Biomaterials (CSBM), executive member of the council of the Chinese Materials Research Society (C-MRS) and Chinese Society for Biomedical Engineering (CSBME) and is a Fellow of international Biomaterials Science and Engineering (FBSE).
His current research activities focus on the molecular design and controlled preparation of novel biomedical polymers, self-assembled biomaterials and nano-biomaterials, vectors for gene therapy, polymeric carriers and controlled drug delivery systems, biomaterials for molecular diagnosis, and biodegradable scaffolds for tissue engineering. Professor Zhongwei Gu has thrice being Chief Scientist of National Basic Research Program of China (National 973 Program) (1999-2004, 2005-2010, 2010-2015) and has being the PI of about 30 funding and research projects. Until now he has published more than 270 papers in Adv. Mater., Angew. Chem. Int. Ed., ACS Nano, Adv. Funct. Mater., Biomaterials, J. Control. Rel. and so on. He also has ~25 patents, composes/translates ~12 books and chapters, and is the invited speaker in many international and domestic conferences.
Klappentext
Among many approaches that have been taken to develop smart delivery systems for drugs and other therapeutic molecules, the most successful ones during the past years have been those which build on a natural process or mimic naturally occuring carriers, such as albumin. Front-line researchers in the booming field of nanobiotechnology describe the most promising approaches for bioinspired drug delivery, encompassing small molecule delivery, delivery of therapeutic proteins and gene delivery. The carriers surveyed include polymeric, proteinaceous and lipid systems on the nanoscale, with a focus on their adaptability for different cargoes and target tissues.
For Medicinal Chemists, Pharmaceutical Chemists, Biotechnologists, Materials Scientists, Pharmaceutical Industry
From the contents:
* Backbone Degradable and Coiled-Coil Based Macromolecular Therapeutics
* Dendritic polymers as targeting nanoscale drug delivery systems for cancer therapy
* Composite Colloidal Nanosystems For Targeted Delivery and Sensing
* Polymeric micelles for cancer-targeted drug delivery
* Biomimetic Polymers for in vivo Drug Delivery
* Drug Delivery from Protein-Based Nanoparticles
* Polymeric gene carriers
* pH-Sensitive Polymeric Nanoparticles as Carriers for Cancer Therapy and Imaging
* Charge-Reversal Polymers for Biodelivery
* Phenylboronic Acid-containing Glucoseresponsive Polymer Materials: Synthesis and Applications in Drug Delivery
* Extracellular pH-Activated Nanocarriers for Enhanced Drug Delivery to Tumors
* Stimulation-Sensitive Drug Delivery Systems
Inhalt
List of Contributors XIII
Preface XIX
1 Backbone Degradable and Coiled-Coil Based Macromolecular Therapeutics 1
Jiyuan Yang and Jind?ich Kopeeek
1.1 Introduction 1
1.2 Water-Soluble Polymers as Carriers of Anticancer Drugs 2
1.2.1 First Generation Conjugates Design, Synthesis, and Activity 2
1.2.2 Analysis of Design Factors That Need Attention 2
1.2.2.1 Design of Conjugates for the Treatment of Noncancerous Diseases 2
1.2.2.2 Combination Therapy Using Polymer-Bound Therapeutics 3
1.2.2.3 New Targeting Strategies 4
1.2.2.4 Relationship Between Detailed Structure of the Conjugates and Their Properties 5
1.2.2.5 Impact of Binding a Drug to a Polymer on the Mechanism of Action 6
1.2.2.6 Mechanism of Internalization and Subcellular Trafficking 7
1.2.2.7 Relationship Between the Molecular Weight of the Carrier and the Efficacy of the Conjugate 7
1.2.3 Design of Second Generation Conjugates Long-Circulating and Backbone Degradable 8
1.2.3.1 RAFT Copolymerization for the Synthesis of Conjugates 8
1.2.3.2 Click Reactions for Chain Extension into Multiblock Copolymers 10
1.2.3.3 Biological Properties of Long-Circulating Macromolecular Therapeutics 10
1.2.4 Summary of Part 2 and Future Prospects 14
1.3 Drug-Free Macromolecular Therapeutics A New Paradigm in Drug Delivery 15
1.3.1 Biorecognition in Hybrid Polymer Systems 15
1.3.2 Coiled-Coils in Biomedical Systems 16
1.3.3 Coiled-Coil Based Drug-Free Macromolecular Therapeutics: Design, In Vitro, and In Vivo Activity 17
1.3.4 Potential, Limitations, and Future Prospect of Drug-Free Macromolecular Therapeutics 18
1.4 General Summary and Outlook 20
Acknowledgments 21
References 21
2 Dendritic Polymers as Targeting Nanoscale Drug Delivery Systems for Cancer Therapy 29
Kui Luo and Zhongwei Gu
2.1 Introduction 29
2.2 Functional Dendritic Polymers Based Drug Delivery Vehicles for Targeting Tumor Therapy via EPR Effect 30
2.2.1 Functional Dendritic Polymers for Encapsulation of Anticancer Drugs 32
2.2.2 Chemical Conjugation Functional Dendritic Polymers as Drug Delivery Systems 37
2.3 Tumor Targeting Moieties Functionalized Dendritic Drug Delivery Vehicles for Cancer Therapy 45
2.4 Conclusion 54
References 54
3 Composite Colloidal Nanosystems for Targeted Delivery and Sensing 61
Pilar Rivera Gil, Moritz Nazarenus, and Wolfgang J. Parak
3.1 Introduction 61
3.1.1 Working Toolkit 62
3.1.2 Engineering a Multifunctional Carrier 63
3.2 Objective 66
3.3 Cellular Behavior of the Carrier 66
3.3.1 Intracellular Fate 66
3.3.2 Biocompatibility 69
3.4 Applications 71
3.4.1 Delivery with Multifunctional PEM Capsules 71
3.4.1.1 Magnetic Targeting and Magnetofection 71
3.4.1.2 Strategies for Controlled Opening 73
3.4.2 Intracellular Ion Sensing 75
3.5 Conclusions 77
Abbreviations 77
References 78
4 Polymeric Micelles for Cancer-Targeted Drug Delivery 85
Huabing Chen, Zhishen Ge, and Kazunori Kataoka
4.1 Introduction 85
4.2 Micelle Formulations in Clinical Development 85
4.3 Particle Size of Micelles 89
4.4 Morphology of Micelles 92
4.5 Targeting Design of Micelles for Enhanced Accumulation and Cell Internalization 94
4.6 Functional Designs of Micelles 96
4.7 Design of Micelles for Gene Delivery 99
4.8 Challenge and Future Perspective 103
References 104
5 Biomimetic Polymers for In Vivo Drug Delivery 109
Wenping Wang and Kinam Park
5.1 Introduction 109
5.2 Commonly Used Biomimetic Polymers and Their Applications in DDS 110
5.2.1 Polylactones and Their Modifications 110
5.2.1.1 Poly(lactic acid) (PLA) 110
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