The Biology and Therapeutic Application of Mesenchymal Cells comprehensively describes the cellular and molecular biology of mesenchymal stem cells and mesenchymal stromal cells, describing their therapeutic potential in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models. Chapters also discuss the current status of the use of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues.
- Provides coverage on both the biology of mesenchymal stem cells and stromal cells, and their therapeutic applications
- Describes the therapeutic potential of mesenchymal stem and stromal cells in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models
- Discusses the current status of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues
- Written and edited by leaders in the field
The Biology and Therapeutic Application of Mesenchymal Cells is an invaluable resource for those studying stem cells, cell biology, genetics, gene or cell therapy, or regenerative medicine.
Kerry Atkinson, MBBS MD DTM&H FRCP FRACP, is an Adjunct Professor at the University of Queensland Centre for Clinical Research in Brisbane, Australia, an Adjunct Professor in the Stem Cell Laboratories, Queensland University of Technology at the Translational Research Institute, Brisbane, Queensland, Australia and a Specialist in Internal Medicine at the Salisbury Medical Centre, Brisbane, Queensland, Australia.
Autorentext
Kerry Atkinson, MBBS MD DTM&H FRCP FRACP, is an Adjunct Professor at the University of Queensland Centre for Clinical Research in Brisbane, Australia, an Adjunct Professor in the Stem Cell Laboratories, Queensland University of Technology at the Translational Research Institute, Brisbane, Queensland, Australia and a Specialist in Internal Medicine at the Salisbury Medical Centre, Brisbane, Queensland, Australia.
Klappentext
The Biology and Therapeutic Application of Mesenchymal Cells comprehensively describes the cellular and molecular biology of mesenchymal stem cells and mesenchymal stromal cells, describing their therapeutic potential in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models. Chapters also discuss the current status of the use of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues.
- Provides coverage on both the biology of mesenchymal stem cells and stromal cells, and their therapeutic applications
- Describes the therapeutic potential of mesenchymal stem and stromal cells in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models
- Discusses the current status of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues
- Written and edited by leaders in the field
The Biology and Therapeutic Application of Mesenchymal Cells is an invaluable resource for those studying stem cells, cell biology, genetics, gene or cell therapy, or regenerative medicine.
Inhalt
Contributors, xxvii
Editor's Preface, xxxv
Section I: An overview of mesenchymal stem cells and mesenchymal stromal cells
1 The mesenchymal stem cell, the mesenchymal stromal cell, and the mesenchymal stromal cell exosome, 3
Kerry Atkinson
2 The nomenclature of mesenchymal stem cells and mesenchymal stromal cells, 8
Armand Keating
Section II: The isolation and ex vivo expansion of mesenchymal stromal cells
3 The isolation and expansion of mesenchymal stromal cells from bone marrow, 13
Celena F. Heazlewood
4 The biology and clinical applications of mesenchymal stromal cells derived from human gestational tissues, 24
Celena F. Heazlewood
5 Human placenta-derived mesenchymal stem/stromal cells: fetal and maternal origins and critical parameters for
ex vivo expansion, 32
Rebecca A. Pelekanos and Varda S. Sardesai
Section III: The cellular and molecular biology of mesenchymal stromal cells
6 Epigenetic regulation of mesenchymal stem/stromal cell growth and multipotentiality, 41
Sarah Elizabeth Hemming, Dimitrios Cakouros, and Stan Gronthos
7 Biological changes in human mesenchymal stromal cells during monolayer culture, 58
Marietta Herrmann and Jennifer J. Bara
8 The effect of three-dimensional aggregates on the biology of mesenchymal stromal cells, 75
Yijun Liu, Ang-Chen Tsai, Xuegang Yuan, and Teng Ma
9 Cellcell signaling pathways that regulate mesenchymal stromal cell differentiation, 91
Leah Etheridge, Rebecca A. Mason, Fatima Saleh, and Paul Genever
10 Regulation of mitochondrial transport in mesenchymal stromal cells, 104
Shravani Mukherjee, Naveen K. Bhatraju, Tanveer Ahmad, and Anurag Agrawal
11 The regulation of adipogenesis from adipose-derived stem/stromal cells, 114
Lin Chen and Lei Liu
12 Modulation of osteogenic differentiation in mesenchymal stromal cells, 131
Sean Gaynard, Jessica Hayes, and Mary Murphy
13 The role of glycogen synthase kinase-3 inhibitors on bone remodeling, 148
K. Jane Escott and Patrick J. O'Shea
14 Early molecular events during in vitro chondrogenesis, 167
Tommy A. Karlsen, Rune B. Jakobsen, and Jan E. Brinchmann
15 The role of the extracellular matrix in the differentiation of mesenchymal stromal cells, 191
Peishun Shou, Qing Chen, and Yufang Shi
16 Effects of hypoxic culture on bone marrow multipotent mesenchymal stromal cells: from bench to bedside, 196
Shih-Chieh Hung
17 The role of cyclic tensile strain on osteogenesis and angiogenesis in human mesenchymal stem/stromal cells, 208
Adisri Charoenpanich, Josephine Bodle, and Elizabeth Loboa
18 The evolving concept of mesenchymal stromal cells in regenerative medicine: from cell differentiation to
secretome, 222
F.G. Teixeira, A. Pires, S.C. Serra, N. Sousa, and A.J. Salgado
19 The secretome of mesenchymal stem/stromal cells undergoing chondrogenic differentiation and those undergoing osteogenic or adipogenic differentiation, 236
Beatriz Rocha, Francisco J. Blanco, and Cristina Ruiz-Romero
20 Mesenchymal stromal cell extracellular vesicles/exosomes, 250
Ronne Wee Yeh Yeo, Ruenn Chai Lai, and Sai Kiang Lim
21 Role of tunneling nanotube crosstalk with distressed cardiomyocytes in controlling the heart repair potential of mesenchymal stromal cells, 264
Anne-Marie Rodriguez and Meriem Mahrouf-Yorgov
22 The preferential homing of mesenchymal stromal cells to sites of inflammation, 286
Catherine Sullivan
23 The role of chemokines in mesenchymal stromal cell homing to sites of inflammation, including infarcted
myocardium, 314
Shan Wang and Yaojiong Wu
24 Live cell imaging and single cell tracking of'mesenchymal stromal cells in vitro, 323
James A. Cornwell, Maria Z. Gutierrez, Richard P. Harvey and Robert E. Nordon
25 The ...