This multimedia educational activity has been designed to help primary care clinicians-the most important facilitators of preventive health care and cancer screening-understand the science behind MCED tests, interpret trial data, and explore the potential role for MCED testing in the routine cancer screening paradigm. The activity will also address the incorporation of MCED testing into primary care practice, including the use of shared decision-making to determine patient eligibility and appropriate diagnostic follow-up in response to a positive test.