"... a must-read for all modern bio-scientists and
engineers working in the field of biotechnology." -
Biotechnology Journal, 2012, 7



A cutting-edge guide on the fundamentals, theory, and
applications of biomechatronic design principles

Biomechatronic Design in Biotechnology presents a
complete methodology of biomechatronics, an emerging variant of the
mechatronics field that marries biology, electronics, and mechanics
to create products where biological and biochemical, technical,
human, management-and-goal, and information systems are combined
and integrated in order to solve a mission that fulfills a human
need. A biomechatronic product includes a biological, mechanical,
and electronic part.

Beginning with an overview of the fundamentals and theory behind
biomechatronic technology, this book describes how general
engineering design science theory can be applied when designing a
technical system where biological species or components are
integrated. Some research methods explored include schemes and
matrices for analyzing the functionality of the designed products,
ranking methods for screening and scoring the best design
solutions, and structuring graphical tools for a thorough
investigation of the subsystems and sub-functions of products.

This insightful guide also:

* Discusses tools for creating shorter development times, thereby
reducing the need for prototype testing and verification

* Presents case study-like examples of the technology used such
as a surface plasmon resonance sensor and a robotic cell culturing
system for human embryonic stem cells

* Provides an interdisciplinary and unifying approach of the many
fields of engineering and biotechnology used in biomechatronic
design

By combining designs between traditional electronic and
mechanical subsystems and biological systems, this book
demonstrates how biotechnology and bioengineering design can
utilize and benefit from commonly used design tools-- and
benefit humanity itself.

Professor Carl-Fredrik Mandenius is head of the Division of
Biotechnology at Linkoping University in Sweden. His main research
interests include biochemical and bio-production engineering,
bioprocess monitoring and control, stem cell technology, and
biosensor technology. He was a director for process R&D at
Pharmacia AB and has coordinated several EU networks on
hESC-derived models for drug testing.

Professor Mats Björkman is head of the Division of
Assembly Technology at Linkoping University in Sweden. His main
research interests include design and operation of flexible
manufacturing systems and equipment. He has also been involved in
research that has developed from traditional mechanical industries
to include areas such as electronic manufacturing and manufacturing
of biotech equipment, as well as pharmaceutical products.

a must-read for all modern bio-scientists and engineers working in the field of biotechnology. Biotechnology Journal, 2012, 7

A cutting-edge guide on the fundamentals, theory, and applications of biomechatronic design principles

Biomechatronic Design in Biotechnology presents a complete methodology of biomechatronics, an emerging variant of the mechatronics field that marries biology, electronics, and mechanics to create products where biological and biochemical, technical, human, management-and-goal, and information systems are combined and integrated in order to solve a mission that fulfills a human need. A biomechatronic product includes a biological, mechanical, and electronic part.

Beginning with an overview of the fundamentals and theory behind biomechatronic technology, this book describes how general engineering design science theory can be applied when designing a technical system where biological species or components are integrated. Some research methods explored include schemes and matrices for analyzing the functionality of the designed products, ranking methods for screening and scoring the best design solutions, and structuring graphical tools for a thorough investigation of the subsystems and sub-functions of products.

This insightful guide also:

• Discusses tools for creating shorter development times, thereby reducing the need for prototype testing and verification
• Presents case study-like examples of the technology used such as a surface plasmon resonance sensor and a robotic cell culturing system for human embryonic stem cells
• Provides an interdisciplinary and unifying approach of the many fields of engineering and biotechnology used in biomechatronic design

By combining designs between traditional electronic and mechanical subsystems and biological systems, this book demonstrates how biotechnology and bioengineering design can utilize and benefit from commonly used design tools and benefit humanity itself.

1 Introduction 1

1.1 Scope of Design / 1

1.2 Definition of Biomechatronic Products / 3

1.3 Principles of Biomechatronics / 4

1.4 Brief History of the Development of Biomechatronic Products and Engineering / 7

1.5 Aim of This Book / 9

References / 10

PART I FUNDAMENTALS 13

2 Conceptual Design Theory 15

2.1 Systematic Design / 15

2.1.1 Design for Products / 15

2.1.2 Origin of the Design Task / 18

2.1.3 Development of Design Thinking / 18

2.1.4 Recent Methods / 20

2.2 Basics of Technical Systems / 21

2.2.1 Energy, Material, and Signals and Their Conversion / 22

2.2.2 Interrelationships of Functions / 22

2.2.3 Interrelationship of Constructions / 25

2.2.4 Interrelationship of Systems / 25

2.3 Psychology in the Systematic Approach / 25

2.4 A General Working Methodology / 26

2.4.1 Analysis for Resolving Technical Problems / 27

2.4.2 Abstraction of Interrelationships of Systems / 28

2.4.3 Synthesis of the Technical System / 28

2.5 Conceptual Design / 28

2.6 Abstraction inOrder to Identify Essential Problems / 29

2.7 Developing the Concepts / 31

2.7.1 Organizing the Development Process / 33

2.8 Concluding Remarks / 34

References / 35

3 Biotechnology and Mechatronic Design 37

3.1 Transduction of the Biological Science into Biotechnology / 37

3.2 Biological Sciences and Their Applications / 39

3.3 Biotechnology and Bioengineering / 42

3.4 Applying Mechatronic Theory to Biotechnology: Biomechatronics / 44

3.5 Conclusions / 47

References / 48

4 Methodology for Utilization of Mechatronic Design Tools 49

4.1 Idea of Applying the Mechatronic Design Tools / 49

4.2 Table of User Needs / 51

4.3 List of Target Specifications / 52

4.4 Concept Generation Chart / 52

4.4.1 Basic Concept Component Chart / 53

4.4.2 Permutation Chart / 54

4.5 Concept Screening Matrix / 55

4.6 Concept Scoring Matrix / 56

4.7 HubkaEder Mapping / 57

4.7.1 Overview HubkaEder Map / 57

4.7.2 Zoom-in HubkaEder Mapping / 59

4.8 Functions Interaction Matrix / 60

4.8.1 Functions Interaction Matrix for Systems and Subsystems / 60

4.8.2 Functions Interaction Matrix for Systems and Transformation Process / 61

4.8.3 Design Structure Matrix / 61

4.9 Anatomical Blueprint / 62

4.10 Conclusions / 63

References / 63

PART II APPLICATIONS 65

5 Blood Glucose Sensors 67

5.1 Background of Blood Glucose Analysis / 67

5.2 Specification of Needs for Blood Glucose Analysis / 70

5.3 Design of Blood Glucos…