The scope of the book is to highlight the diverse roles of cilia in human development and disease. Almost all cell types form cilia and although they were first detected about 200 years ago, their significance was unclear. In the past ten years, it has become obvious that cilia have got sensory functions, as well as roles in motility and their mis-formation or the deregulation of the signaling pathways they control has been associated with defective development and human disease. Although research has concentrated on the role of the cilium in each organ, no effort has been made so far to bring all this information together and relate it to the various human diseases. This book aims to gather all the expertise that has been acquired on primary cilia and translate it into a medical and research context that will be of interest to postgraduate students, researchers, medics and scientists.



Autorentext

Paraskevi Goggolidou received her DPhil in Clinical Medical Sciences from the University of Oxford and her BSc in Molecular Genetics from King's College London. She is currently employed by The Open University and University College London. Dr. Goggolidou has contributed to ten publications.



Zusammenfassung
This book highlights the diverse roles of cilia in human development and disease. Although research has concentrated on the role of cilium in each organ, no effort has been made to bring this information together and relate it to the various human diseases. This book changes that by gathering all the expertise that has been acquired on primary cilia and translating it into a medical and research context that will be of interest to postgraduate students, researchers, physicians, and scientists.

Inhalt

Cilia in the Brain - Development and Disease

Gilbert Lauter, Peter Swoboda and Isabel Tapia-Páez

Cilia in Lung Development and Disease

Laura L. Yates, Hannah M. Mitchison and Charlotte H. Dean

The Role of Cilia in Heart Development and Disease

Sigolène M. Meilhac

Cilia in Kidney Development and Disease

Paraskevi Goggolidou

The Role of Cilia in Pancreatic Development and Disease

Jantje M. Gerdes

The Role of Cilia in Skeletal Development and Disease

Miriam Schmidts

The Role of Cilia in Development and Disease of the Eye

S. Patnaik, V. Kretschmer and H. May-Simera

The Role of Cilia in the Auditory System

Helen May-Simera

Titel
Cilia
Untertitel
Development and Disease
EAN
9781351645690
Format
ePUB
Veröffentlichung
28.02.2018
Digitaler Kopierschutz
Adobe-DRM
Dateigrösse
4.73 MB
Anzahl Seiten
250