Alfie Whitaker and his friends are ready to enjoy their last summer before starting middle school and Alfie would like nothing more than a puppy. When his mother says, "Absolutely not!" Alfie settles for a lizard he catches in his yard. When that lizard goes missing, and Brian 'The Alien' Watley is found to be doing strange experiments in his backyard shed, Alfie and his friends are certain that at any moment, a Franken Lizard will begin terrorizing the neighborhood.

It will be up to them to find out the truth, and stop Franken Lizard!