Science of Synthesis provides a critical review of the synthetic methodology developed from the early 1800s to date for the entire field of organic and organometallic chemistry. As the only resource providing full-text descriptions of organic transformations and synthetic methods as well as experimental procedures, Science of Synthesis is therefore a unique chemical information tool. Over 1000 world-renowned experts have chosen the most important molecular transformations for a class of organic compounds and elaborated on their scope and limitations. The systematic, logical and consistent organization of the synthetic methods for each functional group enables users to quickly find out which methods are useful for a particular synthesis and which are not. Effective and practical experimental procedures can be implemented quickly and easily in the lab.// The content of this e-book was originally published in September 2008.

Science of Synthesis: Houben-Weyl Methods of Molecular Transformations is the entirely new edition of the acclaimed reference series Houben-Weyl, the standard synthetic chemistry resource since 1909. This new edition is published in English and will comprise 48 volumes published between the years 2000 and 2008.

Science of Synthesis is a quality reference work developed by a highly esteemed editorial board to provide a comprehensive and critical selection of reliable organic and organometallic synthetic methods. This unique resource is designed to be the first point of reference when searching for a synthesis strategy.

• Contains the expertise of presently 400 leading chemists worldwide
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• Discusses relevant background information and provides detailed experimental procedures

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32.1 Product Class 1: 1,3-Bis(heteroatom-substituted) Allenes and Analogous Higher Cumulenes
32.2 Product Class 2: Monofunctionalized Allenes and Higher Cumulenes
32.3 Product Class 3: 1,2-Bis(heteroatom-substituted) Alkenes
32.3.1 Product Subclass 1: 1,2-Dihaloalkenes
32.3.2 Product Subclass 2: 1-Halo-2-(organooxy)alkenes
32.3.3 Product Subclass 3: 1-Halo-2-(organochalcogeno)alkenes
32.3.4 Product Subclass 4: 1-Nitrogen-Functionalized 2-Haloalkenes
32.3.5 Product Subclass 5: 1-Phosphorus-Functionalized 2-Haloalkenes
32.3.6 Product Subclass 6: 1,2-Bis(organooxy)alkenes
32.3.7 Product Subclass 7: 1-(Organochalcogeno)-2-(organooxy)alkenes
32.3.8 Product Subclass 8: 1-Nitrogen-Functionalized 2-(Organooxy)alkenes
32.3.9 Product Subclass 9: 1-Phosphorus-Functionalized 2-(Organooxy)alkenes
32.3.10 Product Subclass 10: 1,2-Bis(sulfur-functionalized) Alkenes
32.3.11 Product Subclass 11: 1-Sulfur-Functionalized 2-(Organochalcogeno)-alkenes
32.3.12 Product Subclass 12: 1-Sulfur-Functionalized 2-Nitrogen-Functionalized Alkenes
32.3.13 Product Subclass 13: 1-Sulfur-Functionalized 2-Phosphorus-Functionalized Alkenes
32.3.14 Product Subclass 14: 1,2-Bis(nitrogen-functionalized) Alkenes
32.3.15 Product Subclass 15: 1-Nitrogen-Functionalized 2-Phosphorus-Functionalized Alkenes
32.3.16 Product Subclass 16: 1,2-Bis(phosphorus-functionalized) Alkenes
32.4 Product Class 4: Haloalkenes
32.5 Product Class 5: (Organooxy)alkenes
32.5.1 Product Subclass 1: Enols
32.5.2 Product Subclass 2: Enolates
32.5.3 Product Subclass 3: Enol Ethers
32.5.4 Product Subclass 4: Ene-OX Compounds (X = O, S, Se, Te)
32.5.5 Product Subclass 5: Ene-ON Compounds
32.5.6 Product Subclass 6: Ene-OP Compounds