Science of Synthesis provides a critical review of the synthetic methodology developed from the early 1800s to date for the entire field of organic and organometallic chemistry. As the only resource providing full-text descriptions of organic transformations and synthetic methods as well as experimental procedures, Science of Synthesis is therefore a unique chemical information tool. Over 1000 world-renowned experts have chosen the most important molecular transformations for a class of organic compounds and elaborated on their scope and limitations. The systematic, logical and consistent organization of the synthetic methods for each functional group enables users to quickly find out which methods are useful for a particular synthesis and which are not. Effective and practical experimental procedures can be implemented quickly and easily in the lab.// The content of this e-book was originally published in November 2009.

Science of Synthesis: Houben-Weyl Methods of Molecular Transformations is the entirely new edition of the acclaimed reference series Houben-Weyl, the standard synthetic chemistry resource since 1909. This new edition is published in English and will comprise 48 volumes published between the years 2000 and 2008.

Science of Synthesis is a quality reference work developed by a highly esteemed editorial board to provide a comprehensive and critical selection of reliable organic and organometallic synthetic methods. This unique resource is designed to be the first point of reference when searching for a synthesis strategy.

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47.1 Product Class 1: Alkenes
47.1.1 Synthesis by Alkenation Reactions
47.1.1.1 Wittig and Related Phosphorus-Based Alkenations
47.1.1.2 Peterson Alkenation
47.1.1.3 Julia, Julia–Kocienski, and Related Sulfur-Based Alkenations
47.1.1.4 Alkenation with Metal Carbenes and Related Reactions
47.1.1.5 McMurry Coupling and Related Reductive Dimerization Reactions
47.1.1.6 Alkene Metathesis
47.1.2 Synthesis by Metal-Mediated Coupling Reactions
47.1.2.1 Cross-Coupling and Heck Reactions
47.1.2.2 S_N' Allylations
47.1.2.3 π-Allyl Substitution
47.1.2.4 Oligomerization of Alkenes to Higher Alkenes