Radikalen wurde lange Zeit nachgesagt, daß sie unselektiv reagieren. Neuere Forschungsergebnisse zeigen jedoch: Radikale haben eine enormes Anwendungspotential in der stereoselektiven Synthese. Es kommt eben auf das Know-how an.
The Stereochemistry of Radical Reactions ist eine hervorragende Einführung in die Grundlagen und synthetischen Anwendungen von Radikalen in der stereoselektiven Synthese. Drei führende Wissenschaftler auf diesem Gebiet präsentieren die wichtigen Forschungsergebnisse der letzten Jahre und weisen zukünftige Forschungsrichtungen auf. Darüber hinaus arbeiten die Autoren Regeln aus, die den Leser in die Lage versetzten, seine eigenen Synthesen mit Radikalen zu planen und durchzuführen.
Das ausführliche Literaturverzeichnis macht das Buch zu einer Fundgrube für den Spezialisten und ermöglichet auch dem Nichtexperte einen raschen Einstieg in die Originalliteratur.
Autorentext
Dennis P. Curran is Distinguished Service Professor and head of the Curran Research Group in the Department of Chemistry at the University of Pittsburgh in Pennsylvania. He received his Ph.D. from the University of Rochester in 1979 and has held positions at the University of Wisconsin and University of Pittsburgh. He is an Associate Editor of "Organic Syntheses" and serves as both an Associate Editor and member of the Editorial Advisory Board of "Organic Reactions". His research interests include synthetic radical chemistry, and radical reactions ideally suited for executing sophisticated cascade processes that build complex products from simple starting materials. He is an ISI Highly Cited Researcher, among the top 100 in Chemistry.
Ned Porter graduated from Princeton in 1965 with a B.S. in Chemical Engineering and accepted a position as Assistant Professor at Duke University in 1969, after receiving his Ph.D. with Paul D. Bartlett at Harvard. In 1998, he moved to Vanderbilt University where he is Stevenson Professor of Chemistry. His research interests have centered on the mechanisms of free radical reactions. A continuous research theme has been on the interplay between free radical chemistry, lipids, and oxidative stress in biology.
Zusammenfassung
As little as a decade ago, radicals were regarded as interesting reactive intermediates with little synthetic use. However, recent results show that radicals have an enormous potential for applications in stereoselective reactions - it's all a matter of knowing what method to use and how to apply it.
Three world experts in the field have combined their expertise and present the concepts to understand and even to predict the course of stereoselective radical reactions. In addition, guidelines are established which will enable the readers to plan and carry out their own stereoselective syntheses with radicals. A comprehensive list of references provides an easy access to the primary literature.
The Stereochemistry of Radical Reactions is a highly topical introduction to this burgeoning field of research. Both advanced students and researchers active in the field will welcome this book as a source of concepts and ideas.
Inhalt
From the Contents:
Radical Reactions in Organic Synthesis/
Substrate Control: Radical Cyclizations/
Substrate Control: Cyclic Systems/
Substrate Control: Acyclic Systems/
Chiral Auxiliary Control/
Pair Reactions, Rearrangements and Formation of Alkenes from Radicals