Tumor Microenvironment Regulation of Tumor Expansion is a practical guide to understand and perform research on tumor microenvironments, and to support related clinical decisions. Tumor progression is linked to an imbalance between positive and negative regulators, and mainly depends on the release of specific growth factors by inflammatory or neoplastic cells. Inflammatory infiltrate contributes to tumor progression and the metastatic process, and there are many reports of associations between tumor inflammatory infiltrate, progression, and prognosis. Understanding different contexts of organs is a key factor in improving treatment outcome, especially in new therapeutic treatments targeting components of the tumor microenvironment. This book is a valuable resource for cancer researchers, clinicians, graduate students, and scientists in many biomedical fields who are interested in the complex relationship between the tumor microenvironment and its context in specific organs. - Provides a holistic approach to understanding the crucial role of the tumor microenvironment in tumor progression - Encompasses the basic knowledge necessary to understand and undertake further studies related to tumor microenvironments - Discusses new therapeutic approaches developed to control tumor progression by targeting different components of the tumor microenvironment

Domenico Ribatti is Professor of Human Anatomy, in the Department of Basic Biomedical Sciences, Neurosciences and Sensory Organs, Section of Human Anatomy and Histology, University of Bari Medical School, Italy. He was awarded his M.D. degree in 1981, with full marks. In 1983, he joined the Medical School as Assistant at the Institute of Human Anatomy, University of Bari. In 1984, he took the specialization in Allergology. In 1989, he spent one year in Geneva, working at the Department of Morphology. In 2008, he received the honoris causa degree in Medicine and Pharmacy form the University of Timisoara, Romania. He is the author of over 800 publications and 50 chapters, as well as a number of books for Elsevier/Academic Press including:



Milestones in Immunology (2017)

In Vivo Models to Study Angiogenesis (2017)

Immunology in the Twentieth Century (2018)

Tumor Vascularization (2020)

Tumor Microenvironment Regulation of Tumor Expansion (2021) .

Tumor Microenvironment Regulation of Tumor Expansion is a practical guide to understand and perform research on tumor microenvironments, and to support related clinical decisions.

Tumor progression is linked to an imbalance between positive and negative regulators, and mainly depends on the release of specific growth factors by inflammatory or neoplastic cells. Inflammatory infiltrate contributes to tumor progression and the metastatic process, and there are many reports of associations between tumor inflammatory infiltrate, progression, and prognosis. Understanding different contexts of organs is a key factor in improving treatment outcome, especially in new therapeutic treatments targeting components of the tumor microenvironment.

This book is a valuable resource for cancer researchers, clinicians, graduate students, and scientists in many biomedical fields who are interested in the complex relationship between the tumor microenvironment and its context in specific organs.

• Provides a holistic approach to understanding the crucial role of the tumor microenvironment in tumor progression
• Encompasses the basic knowledge necessary to understand and undertake further studies related to tumor microenvironments
• Discusses new therapeutic approaches developed to control tumor progression by targeting different components of the tumor microenvironment

1. Tumor microenvironment
2. Tumor blood vessels and tumor endothelial cells
3. Tumor angiogenesis
4. Inflammatory cells in tumor microenvironment
5. Therapeutic strategies