This book constitutes the refereed proceedings of the 5th International Conference on Dynamic Data Driven Applications Systems, DDDAS/Infosymbiotics for Reliable AI 2024, held in New Brunswick, NJ, USA, during November 6-8, 2024.

The 43 full papers included in this book were carefully reviewed and selected from 52 submissions. By combining DDDAS and typical AI approaches, the papers address state-of-the-art efforts to create frameworks for enabling new and advanced Science and Technology capabilities to address challenges and create opportunities in important areas, spanning a wide set of areas, such as: materials and aerospace systems; communications networks; energy infrastructures; cyber-security; adverse environmental situations; societal dynamics; computer vision; robotics; laboratory automation; bio-informatics and pharmaceuticals design; and more.