Neuroscience for Clinicians is a comprehensive and clinically relevant survey of emerging concepts on the organization and function of the nervous system and neurologic disease mechanisms. By emphasizing how genetic, molecular, and cellular processes and their interactions control the function of the nervous system, the work will help clinicians understand emerging concepts about the mechanisms of neurologic disorders including neurodegeneration, channelopathies, and synaptic dysfunction that provide potential therapeutic targets . This single-authored textbook utilizes ample figures and tables throughout in order to facilitate retention of the core concepts presented. Divided into 5 sections, the first section includes chapters focused on basic cellular processes. Section 2 includes chapters focused on cell communication while Section 3 focuses on the neuronal microenvironment. The fourth section focuses on the organization and interactions of circuits in the cortex, thalamus, and brainstem, underlying behavioral states such as sleep, sensory processing, and motor control. The fifth section addresses mechanisms of pain and neural control of survival. And the final section covers concepts on mechanisms of emotion, social behavior, memory, language, and executive functions with emphasis on dementia and behavioral disorders.
Autorentext
Eduardo E. Benarroch Professor of Neurology Department of Neurology, Mayo Clinic, Rochester, MN
Zusammenfassung
Neuroscience for Clinicians is a comprehensive and clinically relevant survey of emerging concepts on the organization and function of the nervous system and neurologic disease mechanisms. By emphasizing how genetic, molecular, and cellular processes and their interactions control the function of the nervous system, the work will help clinicians understand emerging concepts about the mechanisms of neurologic disorders including neurodegeneration, channelopathies, and synaptic dysfunction that provide potential therapeutic targets . This single-authored textbook utilizes ample figures and tables throughout in order to facilitate retention of the core concepts presented. Divided into 5 sections, the first section includes chapters focused on basic cellular processes. Section 2 includes chapters focused on cell communication while Section 3 focuses on the neuronal microenvironment. The fourth section focuses on the organization and interactions of circuits in the cortex, thalamus, and brainstem, underlying behavioral states such as sleep, sensory processing, and motor control. The fifth section addresses mechanisms of pain and neural control of survival. And the final section covers concepts on mechanisms of emotion, social behavior, memory, language, and executive functions with emphasis on dementia and behavioral disorders.
Inhalt
Preface Section I: Molecular and Cellular Mechanisms Ch1. Overview: Cellular Components of the Nervous System and Disease Mechanisms Ch2. Organization of the Cell Membranes Ch3. Intracellular Signaling Ch4. DNA: Epigenetic Control of Transcription and Repair Mechanisms Ch5. RNA Metabolism and Control of Translation Ch6. Proteostasis Ch7. Vesicular Trafficking Ch8. Cytoskeleton Ch9. Axonal Transport Ch10. Axon and Myelin Ch11. Mitochondria and Energy Metabolism Ch12. Mechanisms of Cell Death and Axonal Degeneration Ch13. Growth Factors, Survival, and Regeneration Section II: Excitability, Signal Communication, and Plasticity Ch14. Ion Channels and Channelopathies Ch15. Principles of Synaptic Transmission and Presynaptic Synaptopahies Ch16. Neurotransmission, Neuromodulation, and Plasticity Ch17. Glutamatergic Transmission, Plasticity and Synaptopahies Ch18. Inhibitory Amino Acid Transmission and Synaptopahies Ch19. Cholinergic Transmission Ch20. Monoaminergic Neurotransmission Section III: Microenvironment and Mechanisms of Injury and repair Ch21. Astrocyte-Neuron Interactions Ch22. Neuronal Microenvironment Ch23. Microglia and Inflammation in the Nervous System Section III: Neuronal Interactions in Cortical and Subcortical Circuits Ch24. Neocortical Circuits Ch25. Hippocampal and Amygdala Circuits Ch26. Thalamocortical Interactions Ch27. Sleep Ch28. Behavioral State Control Ch29. Sensory Processing Ch30. Cortical Motor Control Ch31. Segmental Spinal Motor Control Ch32. Brainstem Motor Control Ch33. Cerbellum Ch34. Basal ganglia Section V: Homeostatic Systems Ch35. Nociceptors Ch36. Central Pain Processing and Modulation Ch37. Autonomic Nervous System Ch38. Forebrain Control of Homeostasis and Adaptation Section VI: Cortical Networks and Cognitive Domains Ch39. Emotion and Social Cognition Ch40. Episodic Memory, Navigation, and Inner Thoughts Ch41. Language, Speech, and Semantic Cognition Ch42. Cortical Executive Networks and High-level Behavioral and Cognitive Control