Flight of the Wildebeest is a complex narrative weaving together themes of racial injustice, organized crime, international espionage and a global health crisis, all under the metaphorical umbrella of "predator and prey".

The story starts in the middle of the Great Migration at the nexus of the Jim Crow era, when freed slaves - sick of racial persecution, public lynching's, desecration, redlining, etc. - sought freedom elsewhere up in the northern states of America and Canada. This is the pinch point, which initiates the subsequent fictitious events that links to episodes of fictional action that share a connection with true events such as Operation Ranch Hand (Cambodia, Indo-China), Operation Restore Hope (Mogadishu, Somalia), Operation Thesis (Muraroa, South Pacific) and Operation Sea Launch (Christmas Island, South Pacific).

The resultant domestic and foreign debacle precipitate the involvement of two US law enforcement teams of CIA and FBI agents, who subsequently collaborate in solving the exploits of a pair of intrepid snipers, Spotterman and Triggerman, two hunters who are being investigated for other crimes under the auspices of a file code named Operation Wildebeest.

Against this backdrop of domestic and foreign intrigue, the metal of two dedicated malaria vaccine researchers are tested when the WHO (World Health Organization) put out a 'Red Alert' to the global medical fraternity in response to a serious outbreak of a new strain of malaria that is impervious to all current anti-malarial medicines.