Building on the foundation of a one-year introductory course in organic chemistry, Bioorganic Synthesis: An Introduction focuses on organic reactions involved in the biosynthesis of naturally-occurring organic compounds with special emphasis on natural products of pharmacological interest. The book is designed specifically for undergraduate students, rather than as an exhaustive reference work for graduate students or professional researchers and is intended to support undergraduate courses for students majoring in chemistry, biochemistry, biology, pre-medicine, and bioengineering programs who would benefit from a deeper understanding of the chemical logic of reactions carried out in organisms and the origins and uses of the important organic compounds they often produce. The book assumes no prior background in biochemistry and consists of eight chapters: i) a brief review of relevant topics from introductory organic chemistry; ii) presentation of essential organic and biochemical reactions used throughout the book along with a brief introduction to coenzymes; iii) review of basic carbohydrates and the biosynthesis of amino acids; iv) the terpenoid pathway for biosynthesis of all important classes of terpenoids and steroids; v) the acetate pathway for biosynthesis of saturated and unsaturated fatty acids, prostaglandins and acetate-derived polyketide natural products; vi) the biosynthesis of the shikimate pathway products derived from aromatic amino acids; vii) an introduction to biosynthesis of major alkaloids and related nitrogenous compounds; and viii) an overview of laboratory organic synthesis as it relates to the challenges faced by synthetic and medicinal chemists who must recreate intricate natural product structures in the laboratory.

Gary Morrow is Professor Emeritus of Chemistry at The University of Dayton. He joined the Department of Chemistry in 1988.

Introduction Chapter 1. Brief Organic Review Chapter 2. Bioorganic Reactions Chapter 3. Biosynthesis of Carbohydrates and Amino Acids Chapter 4. The Terpenoid Pathway: Products from Mevalonic Acid and Deoxyxylulose Phosphate. Chapter 5. The Acetate Pathway: Biosynthesis of Polyketides and Related Compounds. Fatty Acids: Multiples of Chapter 6. The Shikimate Pathway: Biosynthesis of Phenolic Products from Shikimic Acid Chapter 7. Biosynthesis of Alkaloids and Related Compounds Chapter 8. Organic Synthesis in the Laboratory Some Final Thoughts Study Problems Appendix Suggested Further Readings