This book presents a comprehensive overview of Artificial Intelligence applications in healthcare and behavioral sciences, highlighting how advanced computational methods are transforming clinical practice, public health, and digital health systems. It explains the foundations of machine learning, healthcare data ecosystems, and interoperability standards, and explores AI-driven solutions for epidemiology, population health analytics, telehealth, and mental wellness. The book also examines emerging technologies such as AI-powered diagnostics, smart medical devices, robotics, and clinical decision support systems. In addition, it addresses critical issues including ethics, data security, regulatory frameworks, and responsible AI deployment, making it a valuable resource for researchers, healthcare professionals, policymakers, and technology developers working at the intersection of AI and healthcare innovation.