Pharmaceutical Production Facilities: Design and Applications considers the concepts and constraints that have to be considered in the design of small, medium and large scale production plants. The layout, along with the flow of materials and personnel through facilities are considered with reference to ensuring compliance with current good manufacturing practice. The book explains how clean rooms have developed, and how recent regulations affect their design. The latest concepts for reducing contamination levels from the operator and the product are discussed. It assess current changes in standards and quality control and makes suggestions for the ideal production environment to enable standards to be validated to current standards.

Graham Cole is a Pharmaceutical Engineering Design Consultant specialising in conceptual design, process development and the operation of manufacturing facilities for the production of pharmaceutical dosages, and has worked in the industry for 40 years. He is a fellow of the Institution of Chemical Engineers, a member of the I. Chem. E., and a graduate of the Open University. He has experience of teaching postgraduate pharmaceutical engineering courses in many parts of the world.

Project Design and Management. Site Selection. Process Flow. Pharmaceutical Process Utility Systems. Considerations in the Design of a Pharmaceutical Facility. Cleanrooms. Tablet Production Systems. Tablet Coating Systems. Capsule Filling Systems. The Design of a Sterile and Aseptic Manufacturing Facility. Special Production Systems and Automation. Packaging Systems. Validation. Clean Design.