Science of Synthesis provides a critical review of the synthetic methodology developed from the early 1800s to date for the entire field of organic and organometallic chemistry. As the only resource providing full-text descriptions of organic transformations and synthetic methods as well as experimental procedures, Science of Synthesis is therefore a unique chemical information tool. Over 1000 world-renowned experts have chosen the most important molecular transformations for a class of organic compounds and elaborated on their scope and limitations. The systematic, logical and consistent organization of the synthetic methods for each functional group enables users to quickly find out which methods are useful for a particular synthesis and which are not. Effective and practical experimental procedures can be implemented quickly and easily in the lab.// The content of this e-book was originally published in May 2008.

Science of Synthesis: Houben-Weyl Methods of Molecular Transformations is the entirely new edition of the acclaimed reference series Houben-Weyl, the standard synthetic chemistry resource since 1909. This new edition is published in English and will comprise 48 volumes published between the years 2000 and 2008.

Science of Synthesis is a quality reference work developed by a highly esteemed editorial board to provide a comprehensive and critical selection of reliable organic and organometallic synthetic methods. This unique resource is designed to be the first point of reference when searching for a synthesis strategy.

• Contains the expertise of presently 400 leading chemists worldwide
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• Discusses relevant background information and provides detailed experimental procedures

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37.1 Product Class 1: Dialkyl Ethers
37.1.1 Synthesis from Esters, Aldehydes, Ketones, and Acetals by Reduction or Alkylation
37.1.2 Synthesis by Substitution
37.1.3 Synthesis by Addition to Alkenes
37.1.4 Synthesis from Other Ethers
37.2.1 Synthesis from Alkenes by Metal-Mediated Oxidation
37.2.2 Synthesis from Alkenes with Organic Oxidants
37.2.3 Synthesis by Carbonyl Epoxidation
37.2.4 Synthesis by Ring Closure
37.3 Product Class 3: Oxetanes and Oxetan-3-ones
37.4 Product Class 4: Five-Membered and Larger-Ring
37.4.1 Synthesis by Ring-Closure Reactions, Except Ring-Closing Metathesis
37.4.2 Synthesis by Ring-Closing Metathesis
37.4.3 Synthesis from Other Cyclic Ethers
37.5 Product Class 5: Five-Membered and Larger-Ring Oxacycloalkanes
37.6 Product Class 6: Oxonium Salts
37.7 Product Class 7: Oligo- and Monosaccharide Ethers
37.8 Product Class 8: Ethers as Protecting Groups