This brand new updated edition of the most comprehensive reference book on pancreatic disease details the very latest knowledge on genetics and molecular biological background in terms of anatomy, physiology, pathology, and pathophysiology for all known disorders. Included for the first time, are two brand new sections on the key areas of Autoimmune Pancreatitis and Benign Cystic Neoplasms. In addition, this edition is filled with over 500 high-quality illustrations, line drawings, and radiographs that provide a step-by-step approach to all endoscopic techniques and surgical procedures. Each of these images can be downloaded via an online image bank for use in scientific presentations.
Every existing chapter in The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery, 3rd Edition has been thoroughly revised and updated to include the many changes in clinical practice since publication of the current edition. The book includes new guidelines for non-surgical and surgical treatment; new molecular biologic pathways to support clinical decision making in targeted treatment of pancreatic cancer; new minimally invasive surgical approaches for pancreatic diseases; and the latest knowledge of neuroendocrine tumors and periampullary tumors.
* The most encyclopedic book on the pancreas--providing outstanding and clear guidance for the practicing clinician
* Covers every known pancreatic disorder in detail including its anatomy, physiology, pathology, pathophysiology, diagnosis, and management
* Completely updated with brand new chapters
* Over 500 downloadable illustrations
* An editor and author team of high international repute who present global best-practice
The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery, 3rd Edition is an important book for gastroenterologists and gastrointestinal surgeons worldwide.
Autorentext
The Editors
HANS G. BEGER, MD, FACS(Hon), JSS(Hon), CSS(Hon), Founding Editor, Professor Emeritus of Surgery, c/o University of Ulm, Ulm, Germany
ANDREW L. WARSHAW, MD, FACS, FRCSEd(Hon), W. Gerald Austen Distinguished Professor of Surgery, Harvard Medical School, Surgeon-in-Chief Emeritus, Massachusetts General Hospital, Boston, MA, USA
RALPH H. HRUBAN, MD, Baxley Professor and Director, The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
MARKUS W. BÜCHLER, MD, Professor of Surgery and Chair, Department of Surgery, University of Heidelberg, Heidelberg, Germany
MARKUS M. LERCH, MD, FRCP, Professor and Chair, Department of Medicine A, University Medicine Greifswald, Greifswald, Germany
JOHN P. NEOPTOLEMOS, MA, MB, BCHIR, MD, FRCS, FMEDSCI, Professor of Surgery, Department of Surgery, University of Heidelberg, Heidelberg, Germany
TOORU SHIMOSEGAWA, MD, PhD, Professor, Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
DAVID C. WHITCOMB, MD, PhD, Professor of Medicine, Cell Biology & Physiology, and Human Genetics, Director, UPMC Precision Medicine Service, University of Pittsburgh and UPMC, Pittsburgh, PA, USA
Inhalt
Contributors xiii
Preface xxix
Abbreviations xxx
About the Companion Website xlii
Section 1 Anatomy of the Pancreas 1
1 Development of the Pancreas and Related Structures 3
Brian Lewis and Junhao Mao
2 Anatomy, Histology, and Fine Structure of the Pancreas 10
Daniel S. Longnecker, Fred Gorelick, and Elizabeth D. Thompson
3 Congenital and Inherited Anomalies of the Pancreas 24
Martin Zenker and Markus M. Lerch
Section 2 Physiology and Pathophysiology of Pancreatic Functions 41
4 Physiology of Acinar Cell Secretion 43
Ole H. Petersen
5 Physiology of Duct Cell Secretion 56
Mei Zeng, Laura Vachel, and Shmuel Muallem
6 Pathophysiology of Experimental Pancreatitis 63
Vikas Dudeja, Rajinder Dawra, and Ashok K. Saluja
7 Physiology and Pathophysiology of Function of Sphincter of Oddi 75
Savio George Barreto and James Toouli
8 Neurohormonal and Hormonal Control of Pancreatic Secretion 84
Chung Owyang
9 Regulation of Pancreatic Protein Synthesis and Growth 95
Maria Dolors Sans and John A. Williams
10 Fibrogenesis in the Pancreas: The Role of Stellate Cells 106
Minoti V. Apte, Romano C. Pirola, and Jeremy S. Wilson
11 Fibrogenesis of the Pancreas: The Role of Macrophages 117
Aida Habtezion
12 InsuloAcinar Relationship 123
Keiko Shiratori and Kyoko Shimizu
Section 3 Acute Pancreatitis 133
13 Epidemiology and Etiology of AlcoholInduced Pancreatitis 135
Jeremy S. Wilson, Romano C. Pirola, and Minoti V. Apte
14 Epidemiology and Etiology of Acute Biliary Pancreatitis 146
Michael G.T. Raraty, Andrea Sheel, and John P. Neoptolemos
15 Genetic Factors in Acute Pancreatitis 158
Zachary Zator and Georgios I. Papachristou
16 The Role of the Intestine and Mesenteric Lymph in the Development of Systemic Inflammation and MODS in Severe Acute Pancreatitis 166
Alistair B.J. Escott, Anthony R.J. Phillips, and John A. Windsor
17 The Role of Neurogenic Inflammation in Pancreatitis 173
Jami L. Saloman, Kathryn M. Albers, and Brian M. Davis
18 Molecular, Biochemical, and Metabolic Abnormalities in Acute Pancreatitis 178
Julia Mayerle, Frank Ulrich Weiss, Walter Halangk, and Markus M. Lerch
19 Histopathology of Acute Pancreatitis 193
Günter Klöppel
20 Clinical Classification Systems of Acute Pancreatitis 199
John A. Windsor and Max S. Petrov
21 Clinical Assessment and Biochemical Markers to Objectify Severity and Prognosis 204
Bettina M. Rau and Guido Alsfasser
22 Acute Pancreatitis Associated With Congenital Anomalies 213
Christopher R. Schlieve, Andrew L. Warshaw, and Tracy C. Grikscheit
23 Acute Pancreatitis in Children 219
Mark E. Lowe and Véronique D. Morinville
24 Acute Pancreatitis Associated With Metabolic Disorders, Infectious Diseases, or Drugs 230
Ali A. Aghdassi and Markus M. Lerch
25 Radiologic Diagnosis and Staging of Severe Acute Pancreatitis 238
Yoshihisa Tsuji
Clinical Course and Medical Treatment of Acute Pancreatitis 251
26 Conservative Therapy of Acute Pancreatitis: Volume Substitution and Enteral and Parenteral Nutrition 251
Timothy B. Gardner
27 ICU Treatment of Severe Acute Pancreatitis 258
Scott R. Gunn and David C. Whitcomb
28 Use of Antibiotics in Severe Acute Pancreatitis: Indications and Limitations 265
Rainer Isenmann and Mathias Wittau
Interventional and Surgical Management of Acute Pancreatitis 271
29 Indications for Interventional and Surgical Treatment of Necrotizing Pancreatitis 271
Thomas E. Clancy<...