Time of flight mass spectrometry identifies the elements of a
compound by subjecting a sample of ions to a strong electrical
field. Illuminating emerging analytical techniques in
high-resolution mass spectrometry, Liquid Chromatography
Time-of-Flight Mass Spectrometry shows readers how to analyze
unknown and emerging contaminants--such as antibiotics,
steroids, analgesics--using advanced mass spectrometry
techniques. The text combines theoretical discussion with concrete
examples, making it suitable for analytical chemists, environmental
chemists, organic chemists, medicinal chemists, university research
chemists, and graduate and post-doctorate students.

Imma Ferrer, PHD, has twelve years of hands-on experience in ion
trap, triple quadrupole, and time-of-flight mass spectrometry of
small molecules as applied to environmental and pharmaceutical
chemistry. She is currently a Professional Research Associate of
the Center for Environmental Mass Spectrometry at the University of
Colorado in Boulder, Colorado. She is the author of the book Liquid
Chromatography/Mass Spectrometry, MS/MS and Time-of-Flight MS:
Analysis of Emerging Contaminants. She is also the author of
numerous highly cited papers on the analysis of pesticides and
pharmaceuticals by liquid chromatography mass spectrometry.

E. Michael Thurman, PHD, is a highly cited scientist in
environmental chemistry and an Emeritus Scientist with the U.S.
Geological Survey. He is currently Director of the Center for
Environmental Mass Spectrometry at the University of Colorado, in
Boulder, Colorado. His bibliography consists of more than 200
publications in environmental chemistry, including more than 100
journal articles, twenty proceedings and chapters, and eighty U.S.
Geological Survey publications. Dr. Thurman has published five
books dedicated to the chemical analysis of pesticides and natural
products, sample preparation, and mass spectrometry.

Part I: Principles and Theoretical Aspects of Accurate Mass.

Chapter 1: Accurate Mass Measurements with Orthogonal Axis Time
of Flight Mass Spectrometry (John C. Fjeldsted).

Chapter 2: The Mass Defect, Isotope Clusters, and Accurate Mass
for Elemental Determination (E. Michael Thurman and Imma
Ferrer).

Part II: Tools for Unknown Identification using Accurate
Mass.

Chapter 3: Ion Compostions Determined with Increasing Simplicity
(Andrew H. Grange and G. Wayne Sovocool).

Chapter 4: Use and Existence of Accurate Mass Databases and
Elemental Composition Tools for Target and Non-Target Analyses
(Imma Ferrer and E. Michael Thurman).

Chapter 5: Use of UPLC-(Q)-TOF-MS for Rapid Screening of Organic
Micropollutants in Water (Felix Hernandez, Juan V. Sancho and Maria
Ibanez).

Chapter 6: The Use of Accurate Mass, Isotope Ratios and MS/MS
for the Analysis of PPCPs in Water (Michael C. Zumwalt).

Part III: Applications of LC/TOF-MS for the identification of
small molecules.

Chapter 7: Applications of LC/TOF-MS in the Environmental Field:
When Did it Start and Where is it Going? (Imma Ferrer and E.
Michael Thurman).

Chapter 8: Liquid Chromatography and Ambient Ionization
Time-of-Flight Mass Spectrometry for the Analysis of Genuine and
Counterfeit Pharmaceuticals (Facundo M. Fern ndez, Christina Y.
Hampton, Leonard Nyadong, Arti Navare, Mark Kwasnik).

Chapter 9: Quantitative Analysis of Veterinary Drug Residues by
Sub 2 ?m Particulate High-Performance Liquid Chromatography Columns
and Time-of-Flight Mass Spectrometry (UPLC-TOF)(Anton
Kaufmann).

Chapter 10: Industrial Applications of Liquid Chromatography
Time-of-Flight Mass Spectrometry (Jeffrey R. Gilbert, Jesse L.
Balcer, Scott A. Young, Dan A. Markham, Dennis O. Duebelbeis, and
Paul Lewer).

Chapter 11: Comprehensive Toxicological and Forensic Drug
Screening by LC/TOF-MS (Ilkka Ojanper", Anna Pelander and
Suvi Ojanper).

12. Chapter 12: Application of UPLC/TOF-MS for Residue Analysis
of Veterinary Drugs and Growth Promoting Agents in Products of
Animal Origin (Alida(Linda) A.M. Stolker).

Chapter 13: Accurate Mass Measurements with a Reflectron
Time-of-Flight Mass Spectrometer and the Direct Analysis in Real
Time (DART) Interface for the Identification of Unknown Compounds
Below Masses of 500 Da(O. David Sparkman, Patrick R. Jones, Matthew
Curtis).

Chapter 14: Comparison of LC/TOF-MS and LC/MS-MS for the
Analysis of 100 Pesticides in Food: Finding the "Crossover Point"
(E. Michael Thurman, Imma Ferrer, Paul A. Zavitsanos and Jerry A.
Zweigenbaum).