Bridging the gap between basic scientific advances and the understanding of liver disease -- the extensively revised new edition of the premier text in the field.

The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver's growth, regeneration, metabolic functions, and more.

Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters -- including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology -- provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume:

* Relates molecular physiology to understanding disease pathology and treatment

* Links the science and pathology of the liver to practical clinical applications

* Features 16 new "Horizons" chapters that explore new and emerging science and technology

* Includes plentiful full-color illustrations and figures

The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.

IRWIN M. ARIAS, MD, National Institutes of Health, Bethesda, Maryland, USA.

HARVEY J. ALTER, MD, National Institutes of Health, Bethesda, Maryland, USA.

JAMES L. BOYER, MD, Yale University School of Medicine, New Haven, Connecticut, USA.

DAVID E. COHEN, MD, Weill Cornell Medical College, New York, USA.

DAVID A. SHAFRITZ, MD, Albert Einstein College of Medicine, New York, USA.

SNORRI S. THORGEIRSSON, MD, National Institutes of Health, Bethesda, Maryland, USA.

ALLAN W. WOLKOFF, MD, Albert Einstein College of Medicine, New York, USA.

Inhalt

List of Contributors x

Preface xx

Acknowledgments xxi

Part One: Introduction 1

1 Organizational Principles of the Liver 3
Peter Nagy, Snorri S. Thorgeirsson, and Joe W. Grisham

2 Embryonic Development of the Liver 14
Kenneth S. Zaret, Roque Bort, and Stephen A. Duncan

Part Two: The Cells 23

Section A: Cell Biology of the Liver 25

3 Cytoskeletal Motors: Structure and Function in Hepatocytes 27
Mukesh Kumar, Arnab Gupta, and Roop Mallik

4 Hepatocyte Surface Polarity 36
Anne Müsch and Irwin M. Arias

5 Primary Cilia 50
Carolyn M. Ott

6 Endocytosis in Liver Function and Pathology 62
Micah B. Schott, Barbara Schroeder, and Mark A. McNiven

7 The Hepatocellular Secretory Pathway 75
Catherine L. Jackson and Mark A. McNiven

8 Mitochondrial Function, Dynamics, and Quality Control 86
Marc Liesa, Ilan Benador, Nathanael Miller, and Orian S. Shirihai

9 Nuclear Pore Complex 94
Michelle A. Veronin and Joseph S. Glavy

10 Protein Maturation and Processing at the Endoplasmic Reticulum 108
Ramanujan S. Hegde

11 Protein Degradation and the Lysosomal System 122
Susmita Kaushik and Ana Maria Cuervo

12 Peroxisome Assembly, Degradation, and Disease 137
Rong Hua and Peter K. Kim

13 OrganelleOrganelle Contacts: Origins and Functions 151
Uri Manor

14 Gap and Tight Junctions in Liver: Structure, Function, and Pathology 160
John W. Murray and David C. Spray

15 Ribosome Biogenesis and its Role in Cell Growth and Proliferation in the Liver 174
Katherine I. FarleyBarnes and Susan J. Baserga

16 miRNAs and Hepatocellular Carcinoma 183
Yusuke Yamamoto, Isaku Kohama, and Takahiro Ochiya

17 Hepatocyte Apoptosis: Mechanisms and Relevance in Liver Diseases 195
Harmeet Malhi and Gregory J. Gores

Section B: The Hepatocyte 207

18 Copper Metabolism and the Liver 209
Cynthia Abou Zeid, Ling Yi, and Stephen G. Kaler

19 The Central Role of the Liver in Iron Storage and Regulation of Systemic Iron Homeostasis 215
Tracey A. Rouault, Victor R. Gordeuk, and Gregory J. Anderson

20 Disorders of Bilirubin Metabolism 229
Namita Roy Chowdhury, Yanfeng Li, and Jayanta Roy Chowdhury

21 Hepatic Lipid Droplets in Liver Function and Disease 245
Douglas G. Mashek, Wenqi Cui, Linshan Shang, and Charles P. Najt

22 Lipoprotein Metabolism and Cholesterol Balance 255
Mariana AcuñaAravena and David E. Cohen

Section C: Transporters, Bile Acids, and Cholestasis 269

23 Bile Acid Metabolism in Health and Disease: An Update 271
Tiangang Li and John Y.L. Chiang

24 TGR5 (GPBAR1) in the Liver 286
Verena Keitel, Christoph G.W. Gertzen, Lina Spomer, Holger Gohlke, and Dieter Häussinger

25 Bile Acids as Signaling Molecules 299
Thierry Claudel and Michael Trauner

26 Hepatic Adenosine TriphosphateBinding Cassette Transport Proteins and Their Role in Physiology 313
Peter L.M. Jansen

27 Basolateral Plasma Membrane Organic Anion Transporters 327
M. Sawkat Anwer and Allan W. Wolkoff

28 Hepatic Nuclear Receptors 337
Raymond E. Soccio

29 Molecular Cholestasis 351
Paul Gissen and Richard J. Thompson

30 Pathophysiologic Basis for Alternative Therapies for Cholestasis 364
Claudia D. Fuchs, Emina Halilbasic, and Michael Trauner

31 Adaptive Regulation of Hepatocyte Transporters in Cholestasis 378
James L. Boyer

Section D: NonHepatocyte Cell...