Nancy Skidmore has Alzheimer’s and Eugene Chaney III once more a purpose in life - to end hers. When the moment for Gene to take Nancy to her desired death in Coffeeville arrives she is unexpectedly admitted to the secure unit of a nursing home and he is constrained to call upon the help of his two remaining friends: Bob Crenshaw, a man who has been officially dead for forty years, and Jack Guravitch, a disgraced weatherman in the throes of a midlife crisis. They 'kidnap’ Nancy and drive to Mississippi in a stolen tour bus once owned by Paul McCartney. Along the way they are joined by a young orphan boy called Eric who is searching for his only surviving family member - an exotic dancer named Susan. Last Bus to Coffeeville is a funny story about sad things, a chronicle of lives that have jumped the tracks, a tale of endings and new beginnings.