In order to understand drug metabolism at its most fundamental level, pharmaceutical scientists must be able to analyze drug compound structure and predict possible metabolic pathways in order to avoid the risk of adverse reactions that lead to the withdrawal of a drug from the market. This title is a comprehensive guide for recognizing the chemica

JACK P. UETRECHT is Professor of Pharmacy and Medicine and the Canada Research Chair in Adverse Drug Reactions, University of Toronto, Ontario, Canada. The chair of the Health Canada Scientific Advisory Panel for Hepatotoxicity and Fellow of the Canadian Academy of Health Sciences, Dr. Uetrecht's research is focused on the role of reactive metabolites in immune-mediated and other types of idiosyncratic adverse drug reactions. He serves on the editorial board of Chemical Research in Toxicology, Current Drug Metabolism, Drug Metabolism Letters, Drug Metabolism Reviews, Expert Opinion on Drug Metabolism and Toxicology, and Journal of Immunotoxicology. Dr. Uetrecht received his Ph.D. degree (1972) in organic chemistry from Cornell University, Ithaca, New York and his M.D. degree (1975) from Ohio State University, Columbus. WILLIAM TRAGER is Professor of Medicinal Chemistry, Emeritus, School of Pharmacy, University of Washington, Seattle. His primary research contributions encompass various aspects of drug metabolism, including the molecular basis of metabolically-based drug interactions, quantitative mass spectrometry using stable isotope, and stereoselective metabolism. During his career, he also served as an NIH study section committee member, science advisor to the Seattle FDA laboratory, department chairman, and member of numerous editorial boards. Dr. Trager received the B.Sc. degree in chemistry from the University of San Francisco, California and the Ph.D. degree in medicinal chemistry from the University of Washington, Seattle.

Background for Non-Chemists. Background for Chemists. Oxidation Pathways and the Enzymes That Mediate Them. Reductive Pathways. Hydolytic Pathways. Conjugation Pathways. Reactive Metabolites