Almost twenty years ago, the faculty members of the Department of Pharmacol ogy at the University of Oklahoma College of Medicine developed a review book of medical pharmacology in response to requests from our second year medical students who were preparing to sit for the Part I examination of the National Board of Medical Examiners. The students expressed a need for an organized approach to cope with the volume of basic science curricular material presented during the first two years. Therefore, this book was not developed as a compre hensive text, but rather was designed specifically to provide students with a syn opsis of the basic core of information we deemed essential for their review. This book represents a major revision of our review of medical pharmacology. The book has been updated and expanded, provides current information on ma jor new drugs and information on older drug groups that typically have been covered on previous licensure examinations. The book includes a number of new questions for self-examination. The faculty have endeavored to retain a reason ably concise, relevant and readable review book that will provide the students with a thorough review of pharmacology. Students are advised to refer to com prehensive textbooks, as needed, to fill in any gaps in their knowledge which may be disclosed by the self-examinations.
Inhalt
Section I: General Principles.- Mechanisms of Drug Action.- Absorption of Drugs.- Distribution of Drugs.- Excretion of Drugs.- Determinants of Plasma Concentrations and Dosing Schedules.- Metabolism of Drugs.- Pharmacogenetics.- Review Questions.- Answers.- Section II: Autonomic Drugs.- Parasympathetic Division (Cholinergic).- Autonomic Ganglia.- Neuromuscular Blocking Drugs.- Sympathetic Division (Adrenergic).- Review Questions.- Answers.- Section III: Renal, Cardiovascular and Hematopoietic Drugs.- Diuretics.- Antidiuretic Drugs.- Cardiovascular Drugs.- Calcium Entry Blockers.- Antianginal Drugs.- Antiarrhythmic Drugs.- Congestive Heart Failure.- Drugs Used in the Treatment of Hyperlipoproteinemias.- Antihypertensive Therapy.- Drugs Which Affect Blood Coagulation.- Anti-Anemic (Hematinics).- Review Questions.- Answers.- Section IV: Central Nervous System.- Anesthetic Agents.- General Anesthetics.- Local Anesthetics.- Sedative-Hypnotics.- Benzodiazepines.- Barbiturates.- Other Agents.- Alcohols.- Antiepileptic Drugs.- Antiparkinsonism Drugs.- CNS Muscle Relaxants.- CNS Stimulants.- Antidepressants and Lithium.- Antipsychotics.- Opioids.- Drugs of Abuse.- Review Questions.- Answers.- Section V: Autacoids, NSAIDs and Agents for Arthritis and Gout.- Autacoids.- Histamine and Antihistamines.- Serotonin and Serotonin Antagonists.- Vasoactive Peptides.- Prostaglandins (and Related Agents).- Non-Steroidal Anti-Inflammatory Drugs (NSAIDs).- Miscellaneous Agents Used in Rheumatoid Arthritis.- Miscellaneous Agents Used in Gout.- Review Questions.- Answers.- Section VI: Endocrines.- Thyroid-Antithyroid.- Adrenocortical Steroids.- Parathyroid Hormone and Other Factors Affecting Bone Metabolism.- Insulin.- Ovarian Hormones and Ovulatory Agents.- Androgens and Anabolic Steroids.- Anterior Pituitary and Hypothalamus.- Posterior Pituitary Hormones.- Review Questions.- Answers.- Section VII: Chemotherapy.- Chemotherapy.- Chemotherapy of Microbial Diseases.- Beta-Lactam Antibiotics.- Vancomycin.- Erythromycin.- Lincomycin and Clindamycin.- Chloramphenicol.- Tetracyclines.- Aminoglycosides.- Fluoroquinolones.- Sulfonamides.- Urinary Antiseptics.- Miscellaneous Antibacterial Drugs.- Anti-Tuberculosis Drugs.- Anti-Leprosy Drugs.- Antifungal Agents.- Antiviral Drugs.- Antiseptics and Disinfectants.- Cancer Chemotherapy.- Chemotherapy of Parasitic Diseases.- Review Questions.- Answers.- Section VIII: Miscellaneous Drugs.- Gastrointestinal Drugs.- Respiratory Drugs.- Oxytocic Drugs and Uterine Relaxants.- Toxicology.- Anti-Migraine Drugs.- Vitamins.- U.S. Drug Laws.- Review Questions.- Answers.