In the past decade, CRRT has moved from a niche therapy within specific specialty centers to the standard of care for management of critically ill patients with acute renal failure. Continuous Renal Replacement Therapy provides concise, evidence-based, to-the-point bedside guidance about this treatment modality, offering quick reference answers to clinicians' questions about treatments and situations encountered in daily practice. Organized into sections on Theory; Pratice; Special Situations; and Organizational Issues, Continuous Renal Replacement Therapy provides a complete view of CRRT theory and practice. Generous tables summarize and highlight key points, and key studies and trials are listed in each chapter.

John Kellum is a Professor in the Department of Critical Care Medicine at the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania Rinaldo Bellomo is Professor of Medicine at Melbourne University, Melbourne, Australia Claudio Ronco is Professor of Clinical Nephrology and Medicine at St. Bortolo Hospital, Vicenza, Italy

Section 1: Theory 1. The critically ill patient with acute kidney injury 2. History and rationale for CRRT 3. Terminology and nomenclature 4. Basic principles of solute transport 5. Principles of fluid management 6. Indications, timing and patient selection 7. Extended indications for CRRT 8. Dose adequacy and assessment 9. Acid-base and electrolyte disorders Section 2: Practice 10. Choosing a renal replacement therapy in AKI 11. Vascular access for continuous renal replacement therapy 12. The circuit and the prescription 13. The membrane: size and material 14. Fluids for continuous renal replacement therapy 15. Alarms and troubleshooting 16. Non anticoagulation strategies to optimise circuit function in RRT 17. Anticoagulation 18. Regional Citrate Anticoagulation 19. Drug dosing in CRRT Section 3: Special Situations 20. Renal replacement therapy in children 21. Therapeutic plasma exchange in critical care medicine 22. MARS: molecular adsorbent recirculating system 23. Sorbents 24. Hybrid therapies Section 4: Organizational issues 25. The ICU environment 26. Patient care quality and teamwork 27. Organizational aspects: developing policies and procedures for continuous renal replacement therapies 28. Documentation, billing and reimbursement for continuous renal replacement therapy 29. Machines for CRRT 30. Quality assurance for continuous renal replacement therapies 31. Educational resources