Searching for a Mechanism traces the history of cell bioenergetics from the early notions of science in the Enlightenment through to the end of the twentieth century. Author John N. Prebble's treatment of this history falls into five periods, from the 1600's to the present day. The "bioenergetics revolution" has long been overlooked because it occurred simultaneously as the other major biological revolution of the twentieth century: the development of molecular biology. This book aims to provide the first thorough history of bioenergetics. The story of cell bioenergetics is primarily concerned with the synthesis of ATP (adenosine triphosphate), sometimes referred to as the energy currency of the cell. In fact the term 'bioenergetics' was probably not introduced into the field until Albert Szent-Gyorgyi published a small book under that title in 1957. Despite the twentieth century focus of the subject matter, the history of this field commences with the work of those in the seventeenth century who sought to understand the process of breathing and passes through metabolic biochemistry concluding with the elucidation of the molecular mechanisms of key enzymes in bioenergetics. Although the story of metabolic biochemistry (which is often taken to include bioenergetics) essentially belongs to the twentieth century, progress in this area cannot be understood without recourse to previous centuries. Thus from the seventeenth century onwards it is possible to trace a path of early thinking which eventually laid the ground work for the dramatic success of twentieth century studies.
Autorentext
John N. Prebble is an Honorary Fellow of Royal Holloway, University of London and Emeritus Senior Lecturer in Biochemistry in the School of Biological Sciences.
Zusammenfassung
Searching for a Mechanism traces the history of cell bioenergetics from the early notions of science in the Enlightenment through to the end of the twentieth century. Author John N. Prebble's treatment of this history falls into five periods, from the 1600's to the present day. The "e;bioenergetics revolution"e; has long been overlooked because it occurred simultaneously as the other major biological revolution of the twentieth century: the development of molecular biology. This book aims to provide the first thorough history of bioenergetics. The story of cell bioenergetics is primarily concerned with the synthesis of ATP (adenosine triphosphate), sometimes referred to as the energy currency of the cell. In fact the term 'bioenergetics' was probably not introduced into the field until Albert Szent-Gyorgyi published a small book under that title in 1957. Despite the twentieth century focus of the subject matter, the history of this field commences with the work of those in the seventeenth century who sought to understand the process of breathing and passes through metabolic biochemistry concluding with the elucidation of the molecular mechanisms of key enzymes in bioenergetics. Although the story of metabolic biochemistry (which is often taken to include bioenergetics) essentially belongs to the twentieth century, progress in this area cannot be understood without recourse to previous centuries. Thus from the seventeenth century onwards it is possible to trace a path of early thinking which eventually laid the ground work for the dramatic success of twentieth century studies.
Inhalt
Preface Acknowledgements Abbreviations Chapter 1 Introduction: Respiration, Phosphorylation and Mechanism Chapter 2 From Physiology to Biochemistry: Respiration and Oxidation, 1600 to 1900 Chapter 3 Relating Phosphorylation, Respiration and Oxidation, 1900-1945 Chapter 4: Emergence of the Field of Cell Bioenergetics, 1945-1960 Chapter 5: Defining the Mechanism, 1960-1977 Chapter 6: Discovering Photosynthesis Chapter 7: Elucidating the Photosynthetic Light Reaction Chapter 8: The Impact of Protein Technology, 1977-1997 Chapter 9: The Search for Mechanism References Index