"This book contains extremely detailed and informative content
on structure and function of ligands, receptors, and signalling
intermediates plus interactions ... the extent of detail and
appropriate referencing is impressive." -Microbiology
Today, July 2009

"A very well-written book suitable for use as a reference or
textbook for an undergraduate subject in cell signalling. For
researchers interested in the molecular basis of cell signalling
and how aberrant regulation of cell signalling proteins causes
diseases, this is an excellent resource of biochemical and
structural information." -Australian Biochemist, August
2009

"From basics to details, this is an elegantly written and
carefully edited book. The chapters on cell cycle control and
oncogenesis are particularly fascinating and valuable to biomedical
research. This is the book to have if you are interested in
molecular mechanisms of signal transduction. It is a great
introduction to the literature that will be welcomed by students
and experts alike." -Doody's, January 2009

This text is a concise and accessible introduction to the
dynamic but complex field of signal transduction. Rather than
simply cataloguing all signalling molecules and delineating every
known pathway, this book aims to break signalling down into common
elements and activities - the 'nuts and bolts' of
cellular information exchange.

With an emphasis on clarity of presentation throughout, the book
teaches the basic principles focusing on a mature core of
knowledge, providing students with a foundation of learning in this
complex and potentially confusing subject. It also addresses the
issue of variation in the numbering of key amino acids as well as
featuring interaction with RasMol software, and exercises to aid
understanding.

* An accessible introduction to the complex field of cell
signalling

* Interacts with RasMol software - freely downloadable for
viewing structures in 3D

* Includes exercises and clear instructions in the use of
RasMol

* Well illustrated in full colour throughout

Structure and Function in Cell Signalling is an
invaluable resource to students across a range of life science
degree programmes including biochemistry, cell and molecular
biology, physiology, biomedicine and oncology. This book provides a
clear, accessible introduction to this rapidly expanding field.

John Nelson, Queen's University, Belfast, UK.

With an emphasis on clarity of presentation throughout, the book teaches the basic principles focusing on a mature core of knowledge, providing students with a foundation of learning in this complex and potentially confusing subject. It also addresses the issue of variation in the numbering of key amino acids as well as featuring interaction with RasMol software, and exercises to aid understanding.

Structure and Function in Cell Signalling is a concise and accessible introduction to the dynamic but complex field of signal transduction. Rather than simply cataloguing all signalling molecules and delineating every known pathway, this book aims to break signalling down into common elements and activities - the 'nuts and bolts' of cellular information exchange.

• An accessible introduction to the complex field of cell signalling.
• Interacts with RasMol software - freely downloadable for viewing structures in 3D.
• Includes exercises and clear instructions in the use of RasMol.
• Well illustrated in full colour throughout.

Structure and Function in Cell Signalling will prove invaluable to students across a range of life science degree programmes including biochemistry, cell and molecular biology, physiology, biomedicine and oncology. This book will provide a clear, accessible introduction to this rapidly expanding field.

"A very well-written book suitable for use as a reference or textbook for an undergraduate subject in cell signalling. For researchers interested in the molecular basis of cell signalling and how aberrant regulation of cell signalling proteins causes diseases, this is an excellent resource of biochemical and structural information." Australian Biochemist, August 2009

"From basics to details, this is an elegantly written and carefully edited book. The chapters on cell cycle control and oncogenesis are particularly fascinating and valuable to biomedical research. This is the book to have if you are interested in molecular mechanisms of signal transduction. It is a great introduction to the literature that will be welcomed by students and experts alike." Doody's, January 2009

This text is a concise and accessible introduction to the dynamic but complex field of signal transduction. Rather than simply cataloguing all signalling molecules and delineating every known pathway, this book aims to break signalling down into common elements and activities the 'nuts and bolts' of cellular information exchange.

With an emphasis on clarity of presentation throughout, the book teaches the basic principles focusing on a mature core of knowledge, providing students with a foundation of learning in this complex and potentially confusing subject. It also addresses the issue of variation in the numbering of key amino acids as well as featuring interaction with RasMol software, and exercises to aid understanding.

• An accessible introduction to the complex field of cell signalling
• Interacts with RasMol software freely downloadable for viewing structures in 3D
• Includes exercises and clear instructions in the use of RasMol
• Well illustrated in full colour throughout

Structure and Function in Cell Signalling is an invaluable resource to students across a range of life science degree programmes including biochemistry, cell and molecular biology, physiology, biomedicine and oncology. This book provides a clear, accessible introduction to this rapidly expanding field.

Acknowledgments.

Preface.

1 The components and foundations of signalling.

1.1 Definition of terms used.

1.2 Historical foundations.

1.3 Early milestones in signal transduction research.

1.4 The discovery of receptors and G proteins.

1.5 cAMP pathways.

1.6 cAMP: ancient hunger signal - primitive signalling in amoebazoans and prokaryotes.

References.

2 Enzymes and receptors - quantitative aspects.

2.1 Enzyme steady state assays - Michaelian enzymes.

2.2 Receptor equilibrium binding assays.

2.3 The receptor's environment.

2.4 Guanine nucleotides and the agonist 'affinity-shift' of 7-pass receptors.

References.

3 Modules and motifs in transduction.

3.1 Src homology domains.

3.2 PH superfold modules: PH-, PTB- and PDZ-domains.

3.3 Bcr-homology (BcrH) domains.

3.4 Dbl homology (DH) domains - partners of PH domains.

3.5 Bcl-2 homology (BH) domains.

3.6 Ras bindi…