Central Asia underwent an agricultural transformation in the 20th century that was neither efficient nor sustainable. There is a need for innovations that will remedy these deficits by reversing environmental degradation and ensuring poverty alleviation. This book provides science-based findings and recommendations for restructuring land and water use and agricultural value chains to enable ecologically and economically sound practices that increase resource use efficiency, rehabilitate ecosystem functions, and enhance rural incomes. Innovations were designed in concert with stakeholders. The prospective benefits are shown for the Khorezm region, part of the lower Amudarya region, Uzbekistan, but the findings can be extrapolated to regions facing similar agro-ecological challenges.