Science of Synthesis provides a critical review of the synthetic methodology developed from the early 1800s to date for the entire field of organic and organometallic chemistry. As the only resource providing full-text descriptions of organic transformations and synthetic methods as well as experimental procedures, Science of Synthesis is therefore a unique chemical information tool. Over 1000 world-renowned experts have chosen the most important molecular transformations for a class of organic compounds and elaborated on their scope and limitations. The systematic, logical and consistent organization of the synthetic methods for each functional group enables users to quickly find out which methods are useful for a particular synthesis and which are not. Effective and practical experimental procedures can be implemented quickly and easily in the lab.// The content of this e-book was originally published in September 2006.

Science of Synthesis: Houben-Weyl Methods of Molecular Transformations is the entirely new edition of the acclaimed reference series Houben-Weyl, the standard synthetic chemistry resource since 1909. This new edition is published in English and will comprise 48 volumes published between the years 2000 and 2008.

Science of Synthesis is a quality reference work developed by a highly esteemed editorial board to provide a comprehensive and critical selection of reliable organic and organometallic synthetic methods. This unique resource is designed to be the first point of reference when searching for a synthesis strategy.

• Contains the expertise of presently 400 leading chemists worldwide
• Critically evaluates the preparative applicability and significance of the synthetic methods
• Discusses relevant background information and provides detailed experimental procedures

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20.1 Product Class 1: Acid Halides
20.2 Product Class 2: Carboxylic Acids
20.2.1 Product Subclass 1: Alkanoic Acids
20.2.1.1 Synthesis from Carbonic Acid Derivatives
20.2.1.2 Synthesis from Carboxylic Acid Derivatives
20.2.1.3 Synthesis from Aldehydes, Ketones, and Derivatives (Including Enol Ethers)
20.2.1.4 Synthesis from Organic Halides
20.2.1.5 Synthesis from Alcohols
20.2.1.6 Synthesis from Alkenes (Excluding Reactions withCarboxylic Acid Derivatives)
20.2.1.7 Synthesis by Rearrangement
20.2.1.8 Synthesis with Retention of the Functional Group
20.2.2 Product Subclass 2: Arenedicarboxylic Acids
20.2.3 Product Subclass 3: Butenedioic and Butynedioic Acids
20.2.4 Product Subclass 4: Alkanedioic Acids
20.2.5 Product Subclass 5: 2-Oxo- and 2-Imino-Substituted Alkanoic Acids
20.2.6 Product Subclass 6: 2,2-Diheteroatom-Substituted Alkanoic Acids
20.2.7 Product Subclass 7: 2-Aminoalkanoic Acids (α-Amino Acids)
20.2.8 Product Subclass 8: 2-Heteroatom-Substituted Alkanoic Acids
20.2.9 Product Subclass 9: Alk-2-ynoic Acids
20.2.10 Product Subclass 10: Arenecarboxylic Acids
20.2.11 Product Subclass 11: Alk-2-enoic Acids
20.2.12 Product Subclass 12: 3-Oxoalkanoic and 3,3-Dioxyalkanoic Acids
20.2.13 Product Subclass 13: 3-Heteroatom-Substituted Alkanoic Acids
20.3 Product Class 3: Carboxylic Acid Salts
20.4 Product Class 4: Carboxylic Acid Anhydrides and Their Sulfur, Selenium, and Tellurium Derivatives