Science of Synthesis provides a critical review of the synthetic methodology Science of Synthesis provides a critical review of the synthetic methodology developed from the early 1800s to date for the entire field of organic and organometallic chemistry. As the only resource providing full-text descriptions of organic transformations and synthetic methods as well as experimental procedures, Science of Synthesis is therefore a unique chemical information tool. Over 1000 world-renowned experts have chosen the most important molecular transformations for a class of organic compounds and elaborated on their scope and limitations. The systematic, logical and consistent organization of the synthetic methods for each functional group enables users to quickly find out which methods are useful for a particular synthesis and which are not. Effective and practical experimental procedures can be implemented quickly and easily in the lab.// The content of this e-book was originally published in December 2009.

Science of Synthesis: Houben-Weyl Methods of Molecular Transformations is the entirely new edition of the acclaimed reference series Houben-Weyl, the standard synthetic chemistry resource since 1909. This new edition is published in English and will comprise 48 volumes published between the years 2000 and 2008.

Science of Synthesis is a quality reference work developed by a highly esteemed editorial board to provide a comprehensive and critical selection of reliable organic and organometallic synthetic methods. This unique resource is designed to be the first point of reference when searching for a synthesis strategy.

• Contains the expertise of presently 400 leading chemists worldwide
• Critically evaluates the preparative applicability and significance of the synthetic methods
• Discusses relevant background information and provides detailed experimental procedures

For full information on the Science of Synthesis series, visit the Science of Synthesis Homepage.

47.1 Product Class 1: Alkenes
47.1.3 Synthesis by Pericyclic Reactions
47.1.3.1 Diels–Alder Reactions
47.1.3.2 Ene Reactions
47.1.3.3 Synthesis by Electrocyclic Reactions
47.1.4 Synthesis by Elimination Reactions
47.1.5 Synthesis from Alkynes by Addition Reactions
47.1.5.1 [2+2]-Cycloaddition Reactions
47.1.5.2 Hydrogenation Reactions
47.1.5.3 Hydrometalation and Subsequent Coupling Reactions
47.1.5.4 Carbometalation and Subsequent Coupling Reactions
47.1.6 Synthesis from Arenes and Polyenes by Addition Reactions
47.1.7 Synthesis by Isomerization
47.1.8 Synthesis from Other Alkenes without Isomerization
47.2 Product Class 2: Cyclopropenes
47.3 Product Class 3: Nonconjugated Di-, Tri-, and Oligoenes