The focus of Lake Superior to Rainy Lake is the fur trade along Northwestern Ontario's southern margins, the Voyageurs' Highway from Lake Superior to the Manitoba border. Spanning over three centuries - from the French era to the twenty-first century - the book covers such aspects of North West Company and Hudson's Bay Company history as fur trade rivalry and relationships, trade goods and transportation logistics, mixed-blood families and daily life, and the strategic roles of Michipoten, Fort William, and Rainy Lake. It concludes with a brief examination of the issues facing the fur trade since 1900.