This book is the published proceedings of the Sixth International Symposium on Trace Element Metabolism in Man and Animals. The Symposium was held at the Asilomar Conference Center in Pacific Grove, California, U.S.A. from May 31 through June 5, 1987. The decision to hold TEMA-6 at Asilomar was made at TEMA-5 in 1985. The International Guidance Committee decided to hold the meeting in California in part to recognize the significant cont~i­ butions made to the field of trace element metabolism by Professor Lucille S. Hurley. As such, she was the obvious choice as chair of the local organ­ izing committee. One of the principal goals of Professor Hurley was that TEMA-6 serve as a forum for discussing the use and application of newer methodologies, such as molecular biology, computer modelling and stable isotopes, in studies of trace element metabolism. Based on the comments which the local organizing committee has received, this goal was achieved. The Symposium was attended by 275 scientists from 32 countries covering 6 continents. Twenty-five speakers were chosen for our plenary sessions.

Selenium.- The Global Selenium Agenda.- The Predicament - How Should Selenoproteins be Hydrolyzed and Bioavailability Studies with Selenium Conducted?.- Bioavailability of Selenium in Wheat and Mushrooms as Assessed by a Short-term and a Long-term Experiment.- Selenium Status During Recovery from Malnutrition: Effect of Selenium Supplementation.- Selenium and Glutathione Peroxidase in Mothers Experiencing Sudden Infant Death Syndrome.- Selenium Responsive Conditions and the Concentrations of Selenium in Skeletal Muscle in Young Sheep.- Selenium Status Improved Among Elderly Due to Selenium-Enrichment of Fertilizers in Finland.- Apparent Proteolytic Modification of Glutathione Peroxidase.- Electron Transport and Metalloproteins.- Long-Range Electron Transfer in Ruthenium-Modified Proteins.- Factors Controlling the Rates of Electron Transfer in Proteins.- Kinetic Lability of Zn Bound to Metallothionein (Mt) in Ehrlich Cells.- The Cu-Thiolate Cluster in Mutants of Yeast Metallothionein.- Accumulation of Hepatic Zn7 and Zn/Cu Metallothionein in Copper-Loaded Chicks: Isolation and Characterization.- Factors Influencing the Accumulation of Metallothionein in Rat Blood Cells.- Trace Elements and Endocrine/Exocrine Function: Mn, Zn, Se.- Regulation of Pancreatic Exocrine Function by Manganese.- Effect of Manganese Deficiency on Glucose Transport and Insulin Binding in Rat Adipocytes.- Zinc Absorption in Pancreatic Insufficiency.- Identification of Abnormal Sites of Zn Transport and Metabolism in Patients with Sensory and Endocrine Disorders.- Selenium and Selenoproteins in Tissues with Endocrine Functions.- The Effect of Selenium Deficiency on Plasma Thyroid Hormone Concentrations and on Hepatic Tri-Iodothyronine Production.- Chelation and Other Vehicles for Therapy.- Pyridoxal Isonicotinoyl Hydrazone (PIH) and its Analogues: A New Group of Effective Chelators.- Iron Toxicity and Chelating Therapy.- Toxic and Essential Metal Loss During Chelation Therapy of Lead-Poisoned Children.- Use of Metal Chelating Agents to Modulate Ehrlich Cell Growth Multiple Metal-Ligand Interactions.- Effects of Chelating Compounds Formed on Food Processing on Zinc Metabolism in the Rat.- Changes in Zinc Metabolism During the Use of EDTA.- Trace Elements and Immune Function.- Trace Element Deficiencies and Immune Responsiveness.- Immune Responses as Parametres for Selenium Tolerance Determination in Sheep.- The Mobilization of Storage Iron as a Determinant of Refeeding Infection.- Inflammation-Related Changes in Trace Elements, GSH-Metabolism, Prostaglandins, and Sialic Acid in Bovine Mastitis.- The Effects of Dietary Mo on Ovine Host and Intestinal Parasite.- Trace Elements and Endocrine/Exocrine Function: Cu, Ca, I.- Influence of Hormones on Copper Metalloprotein Levels.- Norepinephrine and Dopamine Distribution in Copper-Deficient Mice.- Effect of Copper Deficiency on Enzyme Secretion from Isolated Pancreatic Acini.- Differential Effect of Copper Deficiency on Plasma Atrial Natriuretic Peptides in Male and Female Rats.- Sexual Differences in Copper Deficiency.- Calmodulin Concentration in Tissues of Zinc and Calcium Deficient Rats.- Effects of Calmodulin Inhibitors on the Cellular Metabolism of 45Ca and 210Pb.- Effect of Moderate Environmental Iodine Deficiency on Adolescent Girls.- Mechanisms of Trace Element Transport.- Transport, Subcellular Distribution and Export of Mn(II) in Rat Liver and Hepatocytes.- Extracellular Transport of Trace Elements.- Incorporation of Copper into Superoxide Dismutase in Culture.- The Role of Albumin in Copper Uptake by Hepatocytes and Fibroblasts.- Structure and Function of Transcuprein, in Transport of Copper by Mammalian Blood Plasma.- Differences in Cu-Transport by Hepatocytes and Fibroblasts.- Neonatal and Adult 64Copper Metabolism in the Pig and Its Relationship to Copper Metabolism in Wilson's Disease.- Epidemiological Studies of Trace Element Nutrition in Man and Animals.- The Role of Selenium in Special Endemic Diseases and Cancer in China.- Wildlife as Indicators of Enzootic Selenium Deficiency.- An Epidemiological Study of a Defined Area of N. Ireland: Serum Zn and Cu.- Zinc, Iron and Copper in the Nutrition of Australian Aboriginal Children.- A Re-Appraisal of the Recommended Zinc Requirements for Grazing Livestock.- The Utilization of Hens' Eggs as a Selenium Monitor in Epidemiological Studies.- Mineral and Trace Element Nutrition of Sheep in Gansu Province, Northern China.- Trace Element Interactions 1.- The Epistemology of Trace Element Balance and Interaction.- Subcellular Changes and Metal Mobilisation in the Livers of Copper-Loaded Rats.- The Interactions among Fe, Zn and Cu Affecting Liver Cu and Femur Zn Concentrations in the Rat.- Interactions between Zinc and Vitamin A Metabolism in Rats and Swine.- Zinc, Copper and Iron Concentrations in Tissues of Anencephalic and Control Fetuses.- Effects of Dietary Boron, Aluminum and Magnesium on Serum Alkaline Phosphatase, Calcium and Phosphorus, and Plasma Cholesterol in Postmenopausal Women.- Trace Elements in Infancy: a Supply/Demand Perspective.- Trace Elements and Development.- Trace Elements in Malnourished Populations.- The Role of Zinc in Prenatal and Postnatal Development.- Teratogenesis as a Function of Maternal Age in Zinc-Deficient Rats.- Zinc Supplements in Infants with Failure to Thrive: Effects on Growth.- Zinc Retention in Relationship to Fat-Free Body and Calcium Accretion in Early and Late Pregnancy.- Zinc (Zn) Absorption in Premature Infants.- Zinc Balance in Premature infants Fed Their Mothers' Milk: Effect of Postnatal Age.- Trace Element Interactions 2.- Trace Mineral and Calcium Interactions.- Dietary Phytate:Zinc and Phytate x Calcium:Zinc Ratios of Lacto-Ovo Vegetarian Trappist Monks.- Zinc, Iron and Copper Interactions in Humans, Rats and Chicks.- Inhibition of Iron Absorption in Man by Manganese and Zinc.- Lipid Parameters in Wilson's Disease Patients on Zinc Therapy.- Effects of Modest Amounts of Wheat Bran and Dietary Protein on Mineral Metabolism of Humans.- Trace Elements and Free Radicals.- First Description of a Variant of E. coli Lacking Superoxide Dismutase Activity Yet Able to Grow Efficiently on Minimal, Oxygenated Medium.- Effect of Selenium (Se) on Peroxidation and Glutathione (GSH) Levels in Murine Mammary Cells.- The Relationship Between Manganese Intake and the Activity of Manganese Superoxide Dismutase in Tissues of Sheep.- Effects of Selenium Intake on the Activity of Superoxide Dismutase and Glutathione Peroxidase and on Malondialdehyde Excretion During the Development of Rat Mammary Carcinogenesis.- Trace Elements, Free Radicals and Lipoperoxidation in Rats.- Contrasting Effects of Selenium and Vitamin E Deficiency on the Anti-Malarial Action of Qinghaosu in Mice.- The Effect of Selenium and Vitamin E Deficiencies on…