Liver Immunology: Principles and Practice, Second Edition begins with important information about the epidemiology and mortality of liver disease worldwide. This information is followed by chapters related to basic immunology, application of liver immunology for diagnosis, and several excellent chapters that provide a solid foundation for understanding immune-mediated liver disease, including those associated with the biliary tree. A chapter on non-hepatic manifestations of immune mediated liver disease helps provide context for how these diseases affect the patient overall. In addition, chapters discuss various discrete immunologically-mediated infectious liver disorders including those related to bacteria, parasites, and all of the classic viruses. Chapters on the traditional autoimmune liver diseases -- primary biliary cirrhosis, autoimmune hepatitis, primary sclerosing cholangitis as well as overlap syndrome - are also included. The breadth of this comprehensive second edition is highlighted by chapters on alcoholic liver disease, non-alcoholic fatty liver disease, and drug-induced liver disease, among others. This invaluable new edition ends with a forward-looking view of future directions and how the field might meet the challenge of refractory patients. Developed by a renowned group of authors, Liver Immunology: Principles and Practice, Second Edition will again serve as a comprehensive textbook by providing an excellent overview for this rapidly evolving field. It greatly adds to the understanding of the pathogenesis of these diseases, while also providing novel insights that can be harnessed into helping improve the care of patients afflicted with various immune-mediated diseases. This volume will again be a must-read for clinicians at all levels, investigators andstudents.
Klappentext
Liver Immunology: Principles and Practice, Second Edition begins with important information about the epidemiology and mortality of liver disease worldwide. This information is followed by chapters related to basic immunology, application of liver immunology for diagnosis, and several excellent chapters that provide a solid foundation for understanding immune-mediated liver disease, including those associated with the biliary tree. A chapter on non-hepatic manifestations of immune mediated liver disease helps provide context for how these diseases affect the patient overall. In addition, chapters discuss various discrete immunologically-mediated infectious liver disorders including those related to bacteria, parasites, and all of the classic viruses. Chapters on the traditional autoimmune liver diseases -- primary biliary cirrhosis, autoimmune hepatitis, primary sclerosing cholangitis as well as overlap syndrome are also included. The breadth of this comprehensive second edition is highlighted by chapters on alcoholic liver disease, non-alcoholic fatty liver disease, and drug-induced liver disease, among others. This invaluable new edition ends with a forward-looking view of future directions and how the field might meet the challenge of refractory patients. Developed by a renowned group of authors, Liver Immunology: Principles and Practice, Second Edition will again serve as a comprehensive textbook by providing an excellent overview for this rapidly evolving field. It greatly adds to the understanding of the pathogenesis of these diseases, while also providing novel insights that can be harnessed into helping improve the care of patients afflicted with various immune-mediated diseases. This volume will again be a must-read for clinicians at all levels, investigators andstudents.
Inhalt
Introductory Comments
About the authors
Preface Meeting the Challenge of Patients with Immune Mediated Liver Disease
Keith D. Lindor, keith.lindor@asu.edu
Foreword: Contemporary Liver Immunology and Immunopathology: Obstacles and Opportunities
Ian R. Mackay, ian.mackay@monash.edu
Chapter 1: Core concepts in immunology
Cliona O'Farrelly & Derek Doherty
Chapter 2: The Geoepidemiology of Autoimmune Liver Disease
Carlo Selmi, Cecilia B. Chighizola, Angela Ceribelli, Maria De Santis, Pier Luigi Meroni, & Renqian Zhong
Chapter 3: Diagnostic Liver Immunology
Christopher Bowlus
Chapter 4: The Liver as a Lymphoid Organ
Percy Knolle
Chapter 5: Innate Immunity and Disorders of the Liver
Mathias Heikenwalder, Percy Knolle, & U. Protzer
Chapter 6: The Liver and Immune Tolerance
Zhigang Tian, Cai Zhang, & Zhe-Xiong Lian
Chapter 7: The Diagnosis and Classification of Immune Mediated Hepatic
Diseases
F. Alvarez
Chapter 8: The Diagnosis and Classification of Immune Mediated Biliary Diseases
Gideon Hirschfield
Chapter 9: Bacterial Infections in Liver
Eirini I. Rigopoulou, Daniel S. Smyk, Timoklia Orfanidou, Dimitrios Bogdanos, &
M. Eric Gershwin
Chapter 10: The Diagnosis and Classification of Parasitic Diseases of the Liver
Shyamapada Mandal & Manisha Mandal
Chapter 11: Viral Diseases of the Liver
Gadi Lalazar & Yaron Ilan
Chapter 12: Hepatitis A: Immune response and virus evolution
Rosa M. Pinto, Albert Bosch, & Gerardo Kaplan
Chapter 13: Immunopathogenesis of Chronic Hepatitis B and the Clinical
Events that Shape its Natural History
Stevan A. Gonzalez & Robert P. Perrillo
Chapter 14: Hepatitis C
Mario U. Mondelli, Stefania Varchetta, & Francesco Negro
Chapter 15: Immunopathogenesis of Hepatitis D
Sebastian Luneman, Jan Grabowski, & Heiner Wedemeyer
Chapter 16: Hepatitis E
Hiroki Takahashi & Mikio Zeniya
Chapter 17: Primary Biliary Cirrhosis
Pietro Invernizzi, Patrick S.C. Leung, Ma Xiong, & M. Eric Gershwin,
Chapter 18: Autoimmune Hepatitis
Diego Vergani, Rodrigo Liberal, & Giorgina Mieli-Vergani
Chapter 19: Primary Sclerosing Cholangitis