Bio-nanotechnology is the key functional technology of the 21st
century. It is a fusion of biology and nanotechnology based on the
principles and chemical pathways of living organisms, and refers to
the functional applications of biomolecules in nanotechnology. It
encompasses the study, creation, and illumination of the
connections between structural molecular biology, nutrition and
nanotechnology, since the development of techniques of
nanotechnology might be guided by studying the structure and
function of the natural nano-molecules found in living cells.
Biology offers a window into the most sophisticated collection of
functional nanostructures that exists.

This book is a comprehensive review of the state of the art in
bio-nanotechnology with an emphasis on the diverse applications in
food and nutrition sciences, biomedicine, agriculture and other
fields. It describes in detail the currently available methods and
contains numerous references to the primary literature, making this
the perfect "field guide" for scientists who want to
explore the fascinating world of bio-nanotechnology. Safety issues
regarding these new technologies are examined in detail.

The book is divided into nine sections - an introductory
section, plus:

* Nanotechnology in nutrition and medicine

* Nanotechnology, health and food technology applications

* Nanotechnology and other versatile applications

* Nanomaterial manufacturing

* Applications of microscopy and magnetic resonance in
nanotechnology

* Applications in enhancing bioavailability and controlling
pathogens

* Safety, toxicology and regulatory aspects

* Future directions of bio-nanotechnology

The book will be of interest to a diverse range of readers in
industry, research and academia, including biologists, biochemists,
food scientists, nutritionists and health professionals.

Debasis Bagchi, PhD, MAC N, CNS, MAIC hE, University of Houston College of Pharmacy, Houston, Texas, USA

Manashi Bagchi, PhD, FAC N, NutriToday LLC, Boston, Massachusetts, USA

Hiroyoshi Moriyama, PhD, FAC N, Showa Pharmaceutical University, Tokyo, Japan

Fereidoon Shahidi, PhD, FAC S, FAOC S, FCIC , FCI FST, FIA FoST, FIFT, FRSC, Department of Biochemistry, Memorial University of Newfoundland, St. John's, Newfoundland, Canada

Bio-nanotechnology is the key functional technology of the 21st century. It is a fusion of biology and nanotechnology based on the principles and chemical pathways of living organisms, and refers to the functional applications of biomolecules in nanotechnology. It encompasses the study, creation, and illumination of the connections between structural molecular biology, nutrition and nanotechnology, since the development of techniques of nanotechnology might be guided by studying the structure and function of the natural nano-molecules found in living cells. Biology offers a window into the most sophisticated collection of functional nanostructures that exists.

This book is a comprehensive review of the state of the art in bio-nanotechnology with an emphasis on the diverse applications in food and nutrition sciences, biomedicine, agriculture and other fields. It describes in detail the currently available methods and contains numerous references to the primary literature, making this the perfect field guide for scientists who want to explore the fascinating world of bio-nanotechnology. Safety issues regarding these new technologies are examined in detail.

The book is divided into nine sections an introductory section, plus:

• Nanotechnology in nutrition and medicine
• Nanotechnology, health and food technology applications
• Nanotechnology and other versatile applications
• Nanomaterial manufacturing
• Applications of microscopy and magnetic resonance in nanotechnology
• Applications in enhancing bioavailability and controlling pathogens
• Safety, toxicology and regulatory aspects
• Future directions of bio-nanotechnology

The book will be of interest to a diverse range of readers in industry, research and academia, including biologists, biochemists, food scientists, nutritionists and health professionals.

Foreword xi

Preface xii

Contributors xv

PART 1 INTRODUCTION 1

Chapter 1 Biomedical Applications of Nanomaterials: An Overview 3
Sunil K. Singh, Paresh P. Kulkarni, Debabrata Dash

Chapter 2 The Challenge of Nanotechnology-Derived Food: Addressing the Concerns of the Public 33
Tomiko Yamaguchi

Chapter 3 Nanotechnology and Public Health: Contributions, Promises, and Premises 47
Masami Matsuda, Ayako Goto, Toshio Ogino, Yoshiaki Tanaka

PART 2 NANOTECHNOLOGY IN NUTRITION AND MEDICINE 67

Chapter 4 Functional Nanomaterials for Biomedical Research: Focus on Bio-Functionalization, Biosynthesis, and Biomedical Applications 69
Murugan Veerapandian, Sathya Sadhasivam, Ramesh Subbiah, Kyusik Yun

Chapter 5 An Overview of Nanoparticle-Assisted Polymerase Chain Reaction Technology 97
Cenchao Shen, Zhizhou Zhang

Chapter 6 A Revolution in Nanomedicines 107
Iulian Bobe, Mitsunori Harada, Ichiro Nakatomi

Chapter 7 Nanotechnology for Regenerative Medicine 124
Yoshikazu Kumashiro, Masayuki Yamato, Teruo Okano

PART 3 NANOTECHNOLOGY, HUMAN HEALTH AND APPLICATIONS 141

Chapter 8 Novel Technologies for the Production of Functional Foods 143
Jack Appiah Ofori, Yun-Hwa Peggy Hsieh

Chapter 9 Nanomedicine: The Revolution of the Big Future with Tiny Medicine 163
Danny D. Meetoo

Chapter 10 Application of -Cyclodextrin in Nanomedicinal Foods and Cosmetics 179
Yukiko Uekaji, Ayako Jo, Akihito Urano, Keiji Terao

Chapter 11 Polymer-Based Nanocomposites for Food Packaging Applications 212
Maurizio Avella, Roberto Avolio, Emilia Di Pace, Maria Emanuela Errico, Gennaro Gentile, Maria Grazia Volpe

Chapter 12 Ultrasound-Mediated Delivery Systems: Using Nano/Microbubbles or Bubble Liposomes 227
Kazuo Maruyama, Ryo Suzuki, Yusuke Oda, Yoko Endo-Takahashi, Yoichi Negishi

Chapter 13 Nanoprobes and Quantum Dots: Employing Nanotechnology to Watch Biology 246
Shampa Chatterjee

Chapter 14 Enhanced Optical Biosensors Based on Nanoplasmonics 252
Kyujung Kim, Youngjin Oh, Donghyun Kim

Chapter 15 Nano-Biosensors for Mimicking Gustatory and Olfactory Senses 270
Kiyoshi Toko, Takeshi Onodera, Yusuke Tahara

Chapter 16 Nanoparticles Inducing Simultaneous Bioreaction in Living Organisms: Critical Sizes for Transition of Biointeractive Behavior 292
Fumio Watari

Chapter 17 Analysis of Immunological Reactions to Nanoscale Foods: Possible Occurrence of Allergic Reaction to Nanoscale Food Particles 304
Eisuke F. Sato, Maki Hashimoto, Masayasu Inoue

Chapter 18 An Overview of Green Nanotechnology 311
Kelvii Wei Guo

Chapter 19 Characterization of Biopolymer and Chitosan-Based Nanocomposites with Antimicrobial Activity 355
Jong-Whan Rhim

Chapter 20 Nanotechnology and its Use in Agriculture 383
Alejandro Pérez-de-Luque, M. Carmen Hermosín

Chapter 21 Applications of Polymeric Nanoparticles with Steroids: A Review 399
Megumu Higaki

Chapter 22 Nanocomposites for Food Packaging: An Overview 406
Tie Lan

Chapter 23 Nanotechnology in Cosmetic Products 414
Howard A. Epstein, Alexander Kielbassa

Chapter 24 Potential Medical Applications of Fullerenes:…