The foundational textbook on the study of virology

Basic Virology, 4th Edition cements this series' position as the leading introductory virology textbook in the world. It's easily read style, outstanding figures, and comprehensive coverage of fundamental topics in virology all account for its immense popularity.

This undergraduate-accessible book covers all the foundational topics in virology, including:

* The basics of virology

* Virological techniques

* Molecular biology

* Pathogenesis of human viral disease

The 4th edition includes new information on the SARS, MERS and COVID-19 coronaviruses, hepatitis C virus, influenza virus, as well as HIV and Ebola. New virological techniques including bioinformatics and advances in viral therapies for human disease are also explored in-depth. The book also includes entirely new sections on metapneumoviruses, dengue virus, and the chikungunya virus.

The foundational textbook on the study of virology

Basic Virology, 4^th Edition cements this series' position as the leading introductory virology textbook in the world. It's easily read style, outstanding figures, and comprehensive coverage of fundamental topics in virology all account for its immense popularity.

This undergraduate-accessible book covers all the foundational topics in virology, including:

• The basics of virology
• Virological techniques
• Molecular biology
• Pathogenesis of human viral disease

The fourth edition includes new information on hepatitis C virus, influenza virus, HIV, Ebola virus, as well as the coronaviruses that cause SARS, MERS and COVID-19. New virological techniques including bioinformatics and advances in viral therapies for human disease are also explored in-depth. The book also includes entirely new sections on metapneumoviruses, dengue virus, and the chikungunya virus.

A full discussion of antiviral therapies, focusing particularly on combination therapies for HCV and HBV is also included. The sections on innate, intrinsic and adaptive immune responses to viral infections have also been updated.

The foundational textbook on the study of virology

Basic Virology, 4^th Edition cements this series' position as the leading introductory virology textbook in the world. It's easily read style, outstanding figures, and comprehensive coverage of fundamental topics in virology all account for its immense popularity.

This undergraduate-accessible book covers all the foundational topics in virology, including:

• The basics of virology
• Virological techniques
• Molecular biology
• Pathogenesis of human viral disease

The 4^th edition includes new information on the SARS, MERS and COVID-19 coronaviruses, hepatitis C virus, influenza virus, as well as HIV and Ebola. New virological techniques including bioinformatics and advances in viral therapies for human disease are also explored in-depth. The book also includes entirely new sections on metapneumoviruses, dengue virus, and the chikungunya virus.

Preface

Preface to the Second Edition

Preface to the Third Edition

Preface to the Fourth Edition

Acknowledgements

[PN]PART I

[PT]VIROLOGY AND VIRAL DISEASE

[PTOC]INTRODUCTIONTHE IMPACT OF VIRUSES ON OUR VIEW OF LIFE

AN OUTLINE OF VIRUS REPLICATION AND VIRAL PATHOGENESIS

PATHOGENESIS OF VIRAL INFECTION

VIRUS DISEASE IN POPULATIONS AND INDIVIDUAL ANIMALS

VIRUSES IN POPULATIONS

ANIMAL MODELS TO STUDY VIRAL PATHOGENESIS

THE DYNAMICS OF VIRUS- HUMAN INTERACTIONS

PATTERNS OF SPECIFIC VIRAL DISEASES OF HUMANS

ADDITIONAL READING FOR PART I

PROBLEMS FOR PART I

[CN]CHAPTER 1

[CT]INTRODUCTIONTHE IMPACT OF VIRUSES ON OUR VIEW OF LIFE

[CTOC] THE SCIENCE OF VIROLOGY

The effect of virus infections on the host organism and populationsviral pathogenesis, virulence, and epidemiology

The interaction between viruses and their hosts

The history of virology

Examples of the impact of viral disease on human history

Examples of the evolutionary impact of the virus-host interaction

The origin of viruses

Viruses have a constructive as well as destructive impact on society

Viruses are not the smallest self-replicating pathogens

QUESTIONS FOR CHAPTER 1

[CN]CHAPTER 2

[CT]AN OUTLINE OF VIRUS REPLICATION AND VIRAL PATHOGENESIS

[CTOC] VIRUS REPLICATION

Stages of virus replication in the cell

PATHOGENESIS OF VIRAL INFECTION

Stages of virus-induced pathology

Initial stages of infectionentry of the virus into the host

The incubation period and spread of virus through the host

Multiplication of virus to high levelsoccurrence of disease symptoms

The later stages of infectionthe immune response

The later stages of infectionvirus spread to the next individual

The later stages of infectionfate of the host

QUESTIONS FOR CHAPTER 2

[CN]CHAPTER 3

[CT]VIRUS DISEASE IN POPULATIONS AND INDIVIDUAL ANIMALS

[CTOC] THE NATURE OF VIRUS RESERVOIRSSome viruses with human reservoirs

Some viruses with vertebrate reservoirs

VIRUSES IN POPULATIONS

Viral epidemiology in small and large populations

Factors affecting the control of viral disease in populations

ANIMAL MODELS TO STUDY VIRAL PATHOGENESIS

A mouse model for studying poxvirus infection and spread

Rabies: where is the virus during its long incubation period?

Herpes simplex virus latency

Murine models

Rabbit models

Guinea pig models

QUESTIONS FOR CHAPTER 3

[CN]CHAPTER 4

[CT]PATTERNS OF SOME VIRAL DISEASES OF HUMANS

[CTOC] THE DYNAMICS OF HUMAN-VIRUS INTERACTIONS

The stable association of viruses with their natural host places specific constraints on the nature of viral disease and mode of persistence

Classification of human disease-causing viruses according to virus-host dynamics

Viral diseases leading to persistence of the virus in the host are generally associated with viruses having long associations with human populations

Viral diseases associated with acute, severe infection are suggestive of zoonoses

PATTERNS OF SPECIFIC VIRAL DISEASES OF HUMANS

Acute infections followed by virus clearing

Colds and respiratory infections

Influenza

Variola

Infection of an accidental target tissue leading to permanent damage despite efficient clearing

Persistent viral infections

Papilloma and polyomavirus infections

Herpesvirus infections and latency

Other complications arising from persistent infections

Viral and subviral diseases with long incubation periods

Rabies

HIVAIDS

Prion diseases

SOME VIRAL INFECTIONS TARGETING SPECIFIC ORGAN SYSTEMS

Viral infections of nerve tissue

Examples of viral encephalit...