The field of pancreatology is moving and advancing the clinical science. This book comprehensively sums up the current knowledge covering all aspects of pancreatitis. It presents up-to-date diagnostics and differential therapies of pancreatitis in a compact manner and includes recently published guidelines. It provides practical assistance addressing clinical pancreatologists and interested colleagues working in the field of gastroenterology, surgery or pathology.
Inhalt
1.A Glimpse of Pancreatitis History171.1.Early thoughts on pancreatic disease171.1.1.Pancreatic anatomy171.2.Acute pancreatitis171.2.1.Nicholaes Tulp171.3.A new interest in pancreatitis181.3.1.Reginald Fitz191.4.Two types of pancreatitis191.4.1.Nicholas Senn201.5.Pancreatitis pathophysiology201.5.1.Opie's common channel hypothesis201.5.2.Alcoholic pancreatitis211.6.Biochemical diagnosis211.7.Classification of acute pancreatitis221.8.Attempts to treat acute pancreatitis222.Epidemiology of Acute Pancreatitis273.Genetics of Pancreatitis343.1.Cationic trypsinogen (PRSS1)343.2.Anionic trypsinogen (PRSS2)353.3.Serine protease inhibitor, Kazal type 1 (SPINK1)353.4.Chymotrypsinogen C (CTRC)363.5.Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)373.6.Alcohol-related chronic pancreatitis384.Physiology of the Normal Pancreas414.1.Exocrine pancreas414.1.1.Enzymes for protein digestion414.1.2.Enzymes for lipid digestion434.1.3.Enzymes for carbohydrate digestion434.1.4.Enzymes for digestion of RNA and DNA434.1.5.Other enzymes and proteins444.1.6.Synthesis and exocytosis of pancreatic digestive enzymes444.1.7.Regulation of enzyme secretion444.2.Endocrine pancreatic function455.Physiology of Acute and Chronic Pancreatitis475.1.Pathophysiology of pancreatic exocrine insufficiency566.Pathology of Pancreatitis636.1.Acute pancreatitis636.1.1.Gross pathology636.1.2.Microscopic findings646.1.3.Complications646.1.3.1.Pseudocyst formation646.1.3.2.Bacterial infection656.2.Chronic pancreatitis656.2.1.Gross pathology656.2.2.Microscopic findings666.2.3.Complications676.2.4.Special forms676.2.4.1.Hereditary chronic pancreatitis686.2.4.2.Tropical pancreatitis686.2.4.3.Obstructive pancreatitis686.2.4.4.Autoimmune pancreatitis686.2.4.5.Groove pancreatitis706.2.5.Chronic pancreatitis and pancreatic cancer707.Classification of Pancreatitis737.1.Acute pancreatitis737.2.Chronic pancreatitis777.3.The new millenniums attempts of classifications818.Acute Pancreatitis908.1.Clinical presentation and laboratory tests908.1.1.Initial symptoms of acute pancreatitis908.1.1.1.Pain908.1.1.2.Other secondary abdominal symptoms918.1.2.Laboratory diagnostic tests of acute pancreatitis918.1.2.1.Enzyme testing frequency918.1.2.2.Amylase928.1.2.3.In critically ill patients938.1.2.4.After propofol938.1.2.5.In smokers938.1.2.6.Urinary trypsinogen-2938.1.3.Hyperlipedaemia938.1.4.Obesity948.1.5.Subcutaneous signs of acute pancreatitis948.1.6.Vascular complications958.1.7.Colonic obstruction and persistent fistulas958.1.7.1.Colonic obstruction in acute pancreatitis958.1.7.2.Fistulas958.2.Severity assessment968.3.Predictors in acute pancreatitis1058.3.1.Prognosis in mild acute pancreatitis1068.3.2.Prognosis in severe acute pancreatitis1068.3.3.Clinical differing mild from severe acute pancreatitis1078.3.4.Other prognostic single factors1098.3.5.Scoring systems1118.3.6.The harmless acute pancreatitis score1138.4.Imaging1148.4.1.Abdominal ultrasound1148.4.2.Cross-sectional imaging1208.5.Therapy1248.5.1.Conservative treatment1248.5.2.Endoscopy 1338.5.3.Endoscopic necrosectomy1458.5.4.Invasive management in acute pancreatitis1489.Chronic Pancreatitis1569.1.Diagnosis1569.1.1.Clinical presentation1569.1.2.Laboratory tests1579.1.3.Imaging1599.1.3.1.Abdominal ultrasound1599.1.3.2.Cross-sectional imaging1679.1.4.Pancreatic function tests1719.1.4.1.Direct pancreatic function tests1729.1.4.2.Indirect pancreatic functional tests1749.2.Therapy1839.2.1.Multidisciplinary approach for alcoholic chronic pancreatitis1839.2.1.1.Medical therapy1869.2.1.2.Nutrition before and after Surgery1939.2.1.3.Pain management1969.2.1.3.1.Lifestyle changes1989.2.1.3.2.Analgesics1989.2.1.3.3.Adjuvant analgesics2009.2.1.3.4.Invasive pain treatment2009.2.2.Interventional endoscopy2029.2.3.Surgical therapy 2099.2.4.Minimally invasive surgery2139.2.5.Islet cell autotransplantation21710.Autoimmune Pancreatitis22310.1.Clinical features22310.1.1.Type 1 AIP22310.1.2.Type 2 AIP22310.2.Diagnosis22410.2.1.Laboratory findings22410.2.2.Diagnostic criteria and differential diagnosis22410.3.Cross-sectional imaging in autoimmune pancreatitis23010.4.Treatment23011.Pancreatitis in Children23411.1.Background23411.2.Acute Pancreatitis23411.3.Pancreatitis due to malformation defects in pancreas23611.4.Trauma23611.5.Recurrent pancreatits23611.6.Chronic pancreatitis23611.7.Exocrine pancreatic insufficiency23711.8.Autoimmune pancreatitis23711.9.Own experience with chronic and recurrent pancreatitis in children23711.10.Organisation23812.Chronic Pancreatitis in Conjunction with Other Diseases24112.1.Primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC)24112.2.IgG4-associated cholangitis24112.3.Connective tissue diseases24112.4.Inflammatory bowel diseases (IBD)24212.5.Infections24213.Organisation of a Modern Chain-Of-Care in Pancreatology24514.Teaching in Pancreatology " the Pancreas 2000 Project24815.Information in the Internet250Index251
Titel
Pancreatitis - Diagnosis and Therapy
EAN
9783837453171
ISBN
978-3-8374-5317-1
Format
E-Book (pdf)
Hersteller
Herausgeber
Genre
Veröffentlichung
09.11.2011
Digitaler Kopierschutz
Wasserzeichen
Dateigrösse
6.71 MB
Anzahl Seiten
256
Untertitel
Englisch
Unerwartete Verzögerung
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