This book constitutes the refereed proceedings of the 6th International Conference on Model and Data Engineering, MEDI 2016, held in Almería, Spain, in September 2016.

The 17 full papers and 10 short papers presented together with 2 invited talks were carefully reviewed and selected from 62 submissions. The papers range on a wide spectrum covering fundamental contributions, applications and tool developments and improvements in model and data engineering activities.

Fundamental contributions in model and data engineering.- Applications and tool developments and improvements in model and data engineering.