Progenitor and stem cells have the ability to renew themselves and change into a variety of specialised types, making them ideal materials for therapy and regenerative medicine. Progenitor and stem cell technologies and therapies reviews the range of progenitor and stem cells available and their therapeutic application.Part one reviews basic principles for the culture of stem cells before discussing technologies for particular cell types. These include human embryonic, induced pluripotent, amniotic and placental, cord and multipotent stem cells. Part two discusses wider issues such as intellectual property, regulation and commercialisation of stem cell technologies and therapies. The final part of the book considers the therapeutic use of stem and progenitor cells. Chapters review the use of adipose tissue-derived stem cells, umbilical cord blood (UCB) stem cells, bone marrow, auditory and oral cavity stem cells. Other chapters cover the use of stem cells in therapies in various clinical areas, including lung, cartilage, urologic, nerve and cardiac repair.With its distinguished editor and international team of contributors, Progenitor and stem cell technologies and therapies is a standard reference for both those researching in cell and tissue biology and engineering as well as medical practitioners investigating the therapeutic use of this important technology. - Reviews the range of progenitor and stem cells available and outlines their therapeutic application - Examines the basic principles for the culture of stem cells before discussing technologies for particular cell types, including human embryonic, induced pluripotent, amniotic and placental, cord and multipotent stem cells - Includes a discussion of wider issues such as intellectual property, regulation and commercialisation of stem cell technologies and therapies
Inhalt
Dedication
Contributor contact details
Introduction
Part I: Basic principles of stem cells
Chapter 1: Basic principles for stem cell culture
Abstract:
1.1 Introduction
1.2 Understanding and standardization of in vitro culture systems
1.3 Quality assurance
1.4 Documentation
1.5 Safety
1.6 Legal, ethical and regulatory compliance
1.7 Education and training
1.8 Conclusion
1.9 Acknowledgement
Chapter 2: Basic principles of human embryonic stem cells
Abstract:
2.1 Introduction: biological properties of human embryonic stem cells (hESC)
2.2 Historical overview
2.3 Human embryonic stem cells (hESC) in therapy - current status and strategies for the future
2.4 Human embryonic stem cells (hESC) in drug discovery - current status and strategies for the future
2.5 Specific mutation-carrying (SMC) human embryonic stem cells (hESC)
2.6 Human embryonic stem cells (hESC) utilization, the next step
2.7 Conclusion
Chapter 3: Basic principles in generating induced pluripotent stem cells
Abstract:
3.1 Introduction
3.2 Evolution of reprogramming and the birth of induced pluripotency
3.3 Current methods for induced reprogramming
3.4 Conclusions and future prospects
Chapter 4: Basic principles of amniotic fluid and placenta stem cells
Abstract:
4.1 Introduction
4.2 Amniotic fluid and placenta in developmental biology
4.3 Isolation and characterization of progenitor cells
4.4 Differentiation of amniotic fluid- and placenta-derived progenitor cells
4.5 In vivo behavior of amniotic fluid stem cells
4.6 Amniotic fluid and placenta for cell therapy
4.7 Conclusion
4.8 Acknowledgment
Chapter 5: Basic principles of cord blood stem cells
Abstract:
5.1 Introduction: history of cord blood stem cell technology
5.2 Cord blood collection, processing and storage
5.3 Public and private cord blood banking
5.4 Cord blood haemopoietic stem cell transplantation
5.5 Cord blood mesenchymal stem cells
5.6 Current research and future developments
5.7 Cord blood transfusion
5.8 Conclusion
Chapter 6: Basic principles of multipotent stem cells
Abstract:
6.1 Introduction
6.2 Hematopoietic stem cells (HSC)
6.3 Mesenchymal stem cells (MSC)
6.4 Adult stem cells with broader potential
6.5 In vitro and in vivo differentiation potential of multipotent adult progenitor cells (MAPC)
6.6 Immunomodulatory properties of multipotent adult progenitor cells (MAPC)
6.7 Conclusion
Part II: Enabling cell therapy
Chapter 7: Intellectual property claims to stem cell technologies: research, clinical testing and product sales
Abstract:
7.1 Introduction
7.2 International overview of patent laws and stem cell policies
7.3 Introduction to the international stem cell patent landscape
7.4 Human embryonic stem cell patents
7.5 Advances in induced pluripotent stem cell patents (iPS cells)
7.6 Models for access to, and management of, stem cell patents
7.7 Conclusion
7.8 Acknowledgments
Chapter 8: Regulatory considerations of stem and progenitor cell-based products: US Food and Drug Administration
Abstract:
8.1 Introduction
8.2 Preparing the cellular component: chemistry, manufacturing and control considerations
8.3 Preclinical testing: pharmacology/toxicology considerations
8.4 Clinical trial considerations
8.5 Combination products: considerations when combining stem/progenitor cells with other components
8.6 Conclusion and future regulatory tools development
8.7 Acknowledgments
Chapter 9: Cell therapy commercialisation
Abstract:
9.1 Introduction: cells as therapies
9.2 The field to date
9.3 Commercialisation
9.4 Manufacturing
9.5 Future trends
9.6 Conclusion
9.7 Acknowledgements
9.8 Sources of further information
Chapter 10: Stem cell tourism
Abstract:
10.1 Introduction
10.2 Scope of the phenomenon
10.3 Problems relating to stem cell tourism
10.4 Responses
10.5 Conclusion
10.6 Acknowledgments
Part III: Tissue-specific progenitor cells
Chapter 11: Adipose tissue-derived stem cell biology and therapy
Abstract:
11.1 Introduction
11.2 Characterization of adipose tissue-derived stromal cells
11.3 Advantages of adipose tissue-derived stem cells over other cell sources
11.4 Adipose tissue-derived stromal cells for cardiovascular repair: a joint clinical and experimental approach
11.5 Conclusion: perspectives and open questions
11.6 Acknowledgements
Chapter 12: Umbilical cord blood (UCB) progenitor and stem cell biology and therapy
Abstract:
12.1 Introduction
12.2 Biological characterization of umbilical cord blood (UCB) stem/progenitor cells
12.3 Therapeutic potential of umbilical cord blood (UCB) stem/progenitor cells for tissue repair or regeneration
12.4 Conclusion and future perspectives
Chapter 13: Auditory progenitor stem cell biology and therapy
Abstract:
13.1 Introduction
13.2 Sources of auditory progenitors
13.3 Transdifferentiation or developmental progression?
13.4 Which is the best cell type and stage for transplantation?
13.5 Future trends
Chapter 14: Olfactory mucosa: neural stem and progenitor cells for nervous system repair and cell models of brain disease
Abstract:
14.1 Introduction
14.2 Olfactory mucosa as source of tissue-resident stem cells
14.3 Cells with clinical application
14.4 Preclinical and clinical studies
14.5 Olfactory stem cell models of human disease
14.6 Conclusion
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