There is growing recognition in the medical profession today that the nonmotor features of Parkinson's Disease (PD) have received insufficient attention, are frequently present in these patients, and can be the source of considerable discomfort and disability for the affected individuals. In Parkinson's Disease and Nonmotor Dysfunction, an outstanding panel of clinicians and scientists provides detailed clinical descriptions and treatment recommendations for these important, but often unrecognized, features of PD. Topics range from behavioral abnormalities and autonomic dysfunction to sleep-related and sensory dysfunction, and include depression, anxiety, dementia, psychosis, obsessionality, gastric and intestinal dysfunction, impaired sexual function, insomnia, excessive daytime sleepiness, and sleep apnea. Attention is also given to several problems (oculomotor dysfunction and fatigue) that tread on, or perhaps cross over, the line between motor and nonmotor dysfunction in PD. The authors review what is known about each type of dysfunction, discussing clinical features, methods of diagnosis, and treatment.
Comprehensive and practical, Parkinson's Disease and Nonmotor Dysfunction offers movement disorder specialists up-to-date guidance on all the nonmotor features of Parkinson's Disease and possible treatments.
Zusammenfassung
Parkinson's Disease and Nonmotor Dysfunction fills a major gap in the current rapidly growing body of knowledge concerning Parkinson's disease. Drs. Pfeiffer and Bodis-Wollner have correctly perceived that many nonmotor features of Parkinson's disease are given insufficient attention in the medical literature. Unfortunately, they are often also given insufficient attention by the practicing neurologists who see these patients. As recently pointed out, there is clearly much more to Parkinson's disease than depletion of the nigrostriatal dopamine system (1). Parkinson's disease (not just m- tiple system atrophy) is a multisystem disorder, both pathologically and in its clinical manifestations. This is clearly true for the various motor system abnormalities, which are not fully corrected by dopamine replacement therapy strategies, but also for the nonmotor system abnormalities that are the subject of this volume. Although recently there has been increased awareness of the cognitive, psychiatric, and sleep disorders commonly associated with Parkinson's disease, many of their manifestations remain under-recognized and their importance in managing patients is underestimated. Even less attention is paid to the myriad of other nonmotor disturbances that plague these patients. For example, among the autonomic disorders, although orthostatic hypotension is well recognized, it is usually attributed to dopaminergic medications rather than to effects of the underlying disease. Urologic disorders are also very familiar in these patients, but may not be properly understood or well managed.
Inhalt
Behavioral Dysfunction in Parkinson's Disease.- Depression.- Anxiety.- Obsessionality.- Dementia.- Psychosis.- Postsurgical Behavioral Changes.- Autonomic Dysfunction in Parkinson's Disease.- Dysphagia.- Gastric Dysfunction.- Intestinal Dysfunction.- Impaired Sexual Function.- Urological Dysfunction.- Cardiovascular Autonomic Dysfunction.- Thermoregulatory Dysfunction.- Respiratory Dysfunction.- Sleep-Related Dysfunction in Parkinson's Disease.- Insomnia.- Rapid Eye Movement Sleep Behavior Disorder.- Excessive Daytime Sleepiness.- Sleep Apnea.- Sensory Dysfunction in Parkinson's Disease.- Visual Dysfunction.- Primary Visual and Visuocognitive Deficits.- Olfactory Dysfunction.- Pain Syndromes and Disorders of Sensation.- Sensorimotor Dysfunction in Parkinson's Disease.- Oculomotor Dysfunction.- Fatigue.