Not since this author's bestselling Manual of Pharmacologic Calculation has there been an available reference for drug data analysis. Incorporating the most relevant parts of that work, Drug Synergism and Dose-Effect Data Analysis focuses on drug combinations and all the quantitative analyses needed to analyze drug combination dose-effect data and to design experiments with two or more compounds. The book contains the statistical methods, the theory, and the computation algorithms needed to analyze single and combination drug data. Numerous examples accompany a presentation that illustrates the calculations and experimental design considerations for modern drug analysis.
Zusammenfassung
Not since this author's bestselling Manual of Pharmacologic Calculation-long out of print-has there been a reference available for drug data analysis, and even that work did not deal with drug combinations. Although pharmacologists and most other scientists know what synergism is, mainstream textbooks tend to neglect it as a quantitative topic. Few
Inhalt
Combinations of Chemicals. Dose-Response Analysis. Linear Regression: A Further Discussion. Calculations for Combination Drug Analysis. The Composite Additive Curve. Quantal Dose-Response Data: Probit and Logit Analysis. Analysis of Drug Combinations over a Range of Drug Ratios. Analysis of a Single Dose Combination. Different Experimental Designs. Response Surface Analysis of Drug Combinations. Nonlinear Regression Analysis. Statistical Concepts and Tests of Hypotheses. Appendix.