This book presents novel classification algorithms for four challenging prediction tasks, namely learning from imbalanced, semi-supervised, multi-instance and multi-label data. The methods are based on fuzzy rough set theory, a mathematical framework used to model uncertainty in data. The book makes two main contributions: helping readers gain a deeper understanding of the underlying mathematical theory; and developing new, intuitive and well-performing classification approaches. The authors bridge the gap between the theoretical proposals of the mathematical model and important challenges in machine learning.