Offers an updated second edition of the comprehensive reference on the use of drugs for veterinary mental health care and behavior modification
This fully revised Second Edition of Veterinary Psychopharmacology offers an authoritative reference to the drugs prescribed to treat psychiatric, psychological, and behavioral disorders in pets. Designed to be an accessible resource, the text is divided into sections on psychopharmacologic principles and clinical psychopharmacology. Comprehensive in scope, the book contains detailed information on pharmacologic intervention for pet mental health and behavior issues, offers thorough explanations of options, and explores why a particular drug should be prescribed and why it works.
Updated to include the recent advances in psychopharmacology for pets, the Second Edition includes new chapters that cover the principles of psychopharmacology, miscellaneous serotonergic agents, anticonvulsants and mood stabilizers, sympatholytic agents, and NMDA antagonists. In addition, the text explains the drug options, including all the information necessary to correct dysfunctions in the brain's chemistry through pharmacologic treatment. This important resource:
* Presents an updated and comprehensive resource for pharmacologic treatments for pet, equine, and zoo animal psychiatric disorders and behavior problems
* Contains in-depth information on drugs that promote neurochemical changes that will alter the mood, emotional state, reactivity, and behavior of the patient, including prescribing options and mechanisms of action
* Includes new chapters on the principles of psychopharmacology, miscellaneous serotonergic agents, mood stabilizers, sympatholytic agents, and NMDA antagonists
Written for veterinarians, veterinary behaviorists, and veterinary students, the updated second edition of Veterinary Psychopharmacology is a complete source for current knowledge on pharmacologic behavior modification.
"Overall, this book packs a substantial amount of useful data into approximately 300 pages. The scope of the book is comprehensive and may include more in-depth information than casual prescribers seek, but it will be a good resource for the practitioners who are interested in immersing themselves into veterinary psychopharmacology." - JAVMA Vol 255 No. 6
Autorentext
The Authors
The Editors
Sharon L. Crowell-Davis, DVM, PhD, DACVB, is a Professor of Behavioral Medicine in the Department of Veterinary Biosciences and Diagnostic Imaging, College of Veterinary Medicine, the University of Georgia in Athens, Georgia, USA.
Thomas F. Murray, PhD, is a Professor of Pharmacology and Provost of Creighton University in Omaha, Nebraska, USA.
Leticia Mattos de Souza Dantas, DVM, MS, PhD, DACVB is a Clinical Assistant Professor of Behavioral Medicine at the University of Georgia Veterinary Teaching Hospital and the Department of Veterinary Biosciences and Diagnostic Imaging at the College of Veterinary Medicine, University of Georgia in Athens, Georgia, USA. She is also the Director and Co-founder of ZooPsych, Inc., a consultancy in Clinical Behavioral Medicine & Therapy in Georgia, USA.
Inhalt
Contributors xxi
Preface xxiii
Acknowledgments xxv
Part I Principles of Veterinary Psychopharmacology 1
1 General Principles of Psychopharmacology 3
Thomas F. Murray
Drug Action 3
Dose Dependence of Drug Interaction with Receptors 4
Structural Features of the Central Nervous System (CNS) and Neurotransmission 5
Biogenic Amine Neurotransmitters and Affective Disorders 8
2 Amino Acid Neurotransmitters: Glutamate, GABA, and the Pharmacology of Benzodiazepines 11
Thomas F. Murray
Introduction 11
Glutamatergic Synapses 11
Pharmacology of Ketamine and Tiletamine 14
GABAergic Synapses 15
3 Biogenic Amine Neurotransmitters: Serotonin 21
Thomas F. Murray
Introduction 21
The Biogenic Amines 21
Serotonin 22
4 Biogenic Amine Transmitters: Acetylcholine, Norepinephrine, and Dopamine 29
Thomas F. Murray
Acetylcholine 29
Norepinephrine 32
Dopamine 37
5 Neuropeptides: Opioids and Oxytocin 43
Thomas F. Murray
Introduction 43
Endogenous Opioid Peptides 43
Oxytocin 47
Part II Practice of Veterinary Psychopharmacology 51
6 Introduction to Clinical Psychopharmacology for Veterinary Medicine 53
Sharon L. CrowellDavis and Leticia Mattos de Souza Dantas
Introduction 53
Prescribing in the United States: The Animal Medicinal Drug Use Clarification Act (AMDUCA 1994) 54
Cost 55
Drug Selection 56
Medicating the Patient 57
Competition Animals 58
Taking the Behavioral History 58
The Behavioral Exam 63
Duration of Treatment 63
Limitations 64
7 Benzodiazepines 67
Leticia Mattos de Souza Dantas and Sharon L. Crowell-Davis
Action 67
Overview of Indications 67
Contraindications, Side Effects, and Adverse Events 69
Overdose 69
Clinical Guidelines 69
Specific Medications 71
I. Alprazolam 71
II. Chlordiazepoxide HC1 73
IV. Clorazepate Dipotassium 78
V. Diazepam 80
VI. Flurazepam Hydrochloride 86
VII. Lorazepam 87
VIII. Oxazepam 89
IX. Triazolam 91
8 Selective Serotonin Reuptake Inhibitors 103
Niwako Ogata, Leticia Mattos de Souza Dantas, and Sharon L. CrowellDavis
Action 103
Overview of Indications 103
Contraindications, Side Effects, and Adverse Events 104
Adverse Drug Interactions 104
Overdose 105
Clinical Guidelines 105
Specific Medications 106
I. Citalopram Hydrobromide 106
II. Fluoxetine Hydrochloride 108
III. Fluvoxamine 115
IV. Paroxetine Hydrochloride 117
V. Sertraline Hydrochloride 119
VI. Escitalopram Oxalate 122
9 Miscellaneous Serotonergic Agents 129
Leticia Mattos de Souza Dantas and Sharon L. CrowellDavis
Introduction 129
Azapirones 129
Action 129
Overview of Indications 129
Contraindications, Side Effects, and Adverse Events 129
Adverse Drug Interactions 129
Overdose 129
Clinical Guidelines 129
Specific Medications 130
I. Buspirone 130
I. Trazodone Hydrochloride 135
10 Anticonvulsants and Mood Stabilizers 147
Sharon L. CrowellDavis, Mami Irimajiri, and Leticia Mattos de Souza Dantas
Action 147
Overview of Indications 148
Clinical Guidelines 148
Specif...