This issue of Fooot and Ankle Clinics will focus on Injectable rh-PDGF in collagen carrier for hindfoot fusion; Vancouver experience of rh-PDGF; B2-A polypeptide in foot ankle fusion; Adipose-derived msc in hindfoot fusion; Polyvinyl for hallux rigidis; New development of novel hammer toe and mt plate; Large BM Intra articular allograft; and many other articles surrounding bone grafts, bone graft substitutes, and biologics.