This book begins with an introduction of pragmatic cluster randomized trials (PCTs) and reviews various pragmatic issues that must be addressed by statisticians at the design stage. It can assist practitioners in the design of PCTs and serve as a textbook for graduate level biostatistics students.

Song Zhang, Ph.D. Professor, Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center.

Chul Ahn, Ph.D. Professor, Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center.

Hong Zhu, Ph.D. Professor, Department of Public Health Sciences, University of Virginia.