CELL BIOLOGY
The ultimate concise introduction to modern cell biology, now updated
Taking an "essentials only" approach, Cell Biology: A Short Course, Third Edition tells the story of cells as the unit of life in a uniquely accessible, student-friendly manner. Completely updated from the previous edition and now in full color, this accessible text features new chapters, a supporting website for students, and online supplemental material including PowerPoint slides for instructors.
As in earlier editions, the authors combine their expertise in the areas of cell biology, physiology, biochemistry, and molecular biology to skillfully present key concepts, illustrating them with clear diagrams and numerous examples from current research. Special sections focus on the importance of cell biology in medicine and industry today, with extensive cross-referencing to real-world research and development. In updating this text, the authors have provided such new material as:
* A chapter on the cell biology of the immune system
* Discussion of stem cells, cytokine receptors, the cell biology of cancer, and cell division
* "Medical Relevance" text boxes
* A family tree of organisms to reinforce cell biology differences among major taxa
* Online supplemental information for students, including interactive quizzes and animations
Also included are a detailed description of intercellular signaling and a chapter devoted to a case study of cystic fi brosis. Review questions are included at the end of each chapter, as well as a full glossary of key words and phrases to help make even the most complex concepts easy to master. Ideally suited for undergraduate cell biology/biology majors, pre-med students, and graduate and medical school courses in cell biology, this Third Edition of Cell Biology is the most integrated introduction available on this fascinating and timely subject
Visit the companion website www.wileyshortcourse.com/cellbiology for supplementary material, including animations, video, and useful links and references
Autorentext
Steve Bolsover is professor of Cell Physiology in the Department of Physiology. His widely published research concerns the role of calcium as an intracellular messenger.
Jeremy Hyams is Professor of Cell Biology in the Department of Biology.
Elizabeth Shephard is a Professor in the Department of Biochemistry and Molecular Biology.
Hugh White is a Senior Lecturer in the Department of Biochemistry and Molecular Biology.
Zusammenfassung
CELL BIOLOGY
The ultimate concise introduction to modern cell biology, now updated
Taking an essentials only approach, Cell Biology: A Short Course, Third Edition tells the story of cells as the unit of life in a uniquely accessible, student-friendly manner. Completely updated from the previous edition and now in full color, this accessible text features new chapters, a supporting website for students, and online supplemental material including PowerPoint slides for instructors.
As in earlier editions, the authors combine their expertise in the areas of cell biology, physiology, biochemistry, and molecular biology to skillfully present key concepts, illustrating them with clear diagrams and numerous examples from current research. Special sections focus on the importance of cell biology in medicine and industry today, with extensive cross-referencing to real-world research and development. In updating this text, the authors have provided such new material as:
- A chapter on the cell biology of the immune system
- Discussion of stem cells, cytokine receptors, the cell biology of cancer, and cell division
- Medical Relevance text boxes
- A family tree of organisms to reinforce cell biology differences among major taxa
- Online supplemental information for students, including interactive quizzes and animations
Also included are a detailed description of intercellular signaling and a chapter devoted to a case study of cystic fi brosis. Review questions are included at the end of each chapter, as well as a full glossary of key words and phrases to help make even the most complex concepts easy to master. Ideally suited for undergraduate cell biology/biology majors, pre-med students, and graduate and medical school courses in cell biology, this Third Edition of Cell Biology is the most integrated introduction available on this fascinating and timely subject
Visit the companion website www.wileyshortcourse.com/cellbiology for supplementary material, including animations, video, and useful links and references
Inhalt
Preface xiii
1 Cells And Tissues 1
Principles of Microscopy 1
The Light Microscope 2
The Electron Microscope 3
The Scanning Electron Microscope 4
Only Two Types of Cell 7
Cell Division 8
Viruses 9
Origin of Eukaryotic Cells 10
Cell Specialization in Animals 11
Stem Cells and Tissue Replacement 13
The Cell Wall 14
2 Water and Macromolecules 17
The Chemical Bond: Sharing Electrons 17
Interactions with Water: Solutions 18
Ionic Compounds Will Dissolve Only in Polar Solvents 18
Acids are Molecules That Give H+ to Water 20
Bases are Molecules that Take H+ from Water 22
Isoelectric Point 22
A Hydrogen Bond Forms When a Hydrogen Atom is Shared 23
Biological Macromolecules 23
Carbohydrates: Candy and Canes 23
An Assortment of Sweets 24
Disaccharides 25
Out of the Sweet Comes Forth Strength 26
Modified Sugars 27
Oxidation and Reduction Involve the Movement of Electrons 31
Amino Acids, Polypeptides, and Proteins 32
Lipids 33
Hydrolysis 34
3 Membranes and Organelles 43
Basic Properties of Cell Membranes 43
Straight Through the Membrane: Diffusion Through the Bilayer 44
Cell Junctions 44
Organelles Bounded by Double-Membrane Envelopes 47
The Nucleus 47
Mitochondria 48
Organelles Bounded by Single Membranes 49
Peroxisomes 49
Endoplasmic Reticulum 49
Golgi Apparatus 50
Lysosomes 50
4 DNA Structure and The Genetic Code 53
The Structure of DNA 53
The DNA Molecule is a Double Helix 53
The Two DNA Chains are Complementary 55
Different Forms of DNA 55
DNA as the Genetic Material 55
Packaging of DNA molecules Into Chromosomes 57
Eukaryotic Chromosomes and Chromatin Structure 57
Prokaryotic Chromosomes 58
Plasmids 59
Viruses 59
The Genetic Code 59
Amino Acid Names are Abbreviated 60
The Code is Degenerate But Unambiguous 60
Start and Stop Codons and the Reading Frame 63
The Code is Nearly Universal 64
Missense Mutations 64
5 DNA as A Data Storage Medium 67
DNA Replication 67
The DNA Replication Fork 67
Proteins Open Up the DNA Double Helix During Replication 67
DnaA Protein 68
DnaB and DnaC Proteins 68
Single-Strand Binding Proteins 68
Biochemistry of DNA Replication 68
DNA Synthesis Requires an RNA Primer 69
RNA Primers are Removed 71
The Self-Correcting DNA Polymerase 71
Mismatch Repair Backs Up the Proofreading Mechanism 71
DNA Repair After Replication 72
Spontaneous and Chemically Induced Base Changes 72
Repair Processes 73
Gene Structure and Organization in Eukaryotes 75
Introns and Exons: Additional Complexity in Eukaryotic Genes 75
The Major Classes of Eukaryotic DNA 76
Gene Nomenclature 78
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