Seven Generations of the Barnes Family begins in the 1700s with William Barnes and his wife, Agnes Potts Barnes, and their five children. It then follows the descendants of each of their children into the twenty-first century. The births, deaths, marriages, and burial places are given for each person, along with the names of their parents and children and how they are related to William and Agnes.

There are 231 photographs of ancestors and some drawings and photographs of headstones. Sources such as indentures, obituaries, wedding news, old census reports, school attendance records, military documents, and many other documents are included.